Liquid-phase detection of biological targets with magnetic marker and superconducting quantum interference device

Keiji Enpuku, Yuki Sugimoto, Yuya Tamai, Akira Tsukamoto, Takako Mizoguchi, Akihiko Kandori, Naoki Usuki, Hisao Kanzaki, Kohji Yoshinaga, Yoshinori Sugiura, Hiroyuki Kuma, Naotaka Hamasaki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Liquid-phase detection of biological targets utilizing magnetic marker and superconducting quantum interference device (SQUID) magnetometer is shown. In this method, magnetic markers are coupled to the biological targets, and the binding reaction between them is detected by measuring the magnetic signal from the bound markers. Detection can be done in the liquid phase, i.e., we can detect only the bound markers even in the presence of unbound (free) markers. Since the detection principle is based on the different magnetic properties between the free and bound markers, we clarified the Brownian relaxation of the free markers and the Neel relaxation of the bound markers. Usefulness of the present method is demonstrated from the detection of the biological targets, such as biotincoated polymer beads, IgE and Candida albicans.

Original languageEnglish
Pages (from-to)315-322
Number of pages8
JournalIEICE Transactions on Electronics
VolumeE92-C
Issue number3
DOIs
Publication statusPublished - Jan 1 2009

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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