Abstract
Purpose: To compare retrospectively liver and renal function after repeated exposure (twice) to sevoflurane or isoflurane. Methods: Sixty patients were studied for liver and renal function after repeated exposure within 30 to 180 days to sevoflurane (30 patients) or isoflurane (30 patients). Serum concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBil), alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GTP), blood urea nitrogen (BUN) and creatinine (Cr) were measured before and, 1, 3, 7, and 14 days after surgery. Qualitative analyses of urinary protein and glucose were done 1, 3, and 7 days after surgery. Results: The number of patients with abnormal values in AST, ALT and GTP was larger in the isoflurane than in the sevoflurane group. BUN and Cr were within normal range after anaesthesia in either group. Renal excretion of protein and glucose increased one and three days after anaesthesia with no difference between the anaesthetics. None of the variables showed differences between the first and second anaesthesia after either anaesthetic. Conclusion: Repeat exposure to sevoflurane or isoflurane within 30 to 180 clays had no additional risk of increasing serum concentration of liver enzymes or increasing urinary excretion of protein and glucose compared with the first exposure to the same anaesthetic.
| Original language | English |
|---|---|
| Pages (from-to) | 789-793 |
| Number of pages | 5 |
| Journal | Canadian Journal of Anaesthesia |
| Volume | 45 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Jan 1 1998 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Anesthesiology and Pain Medicine
Cite this
Liver and renal function after repeated sevoflurane or isoflurane anaesthesia. / Nishiyama, Tomoki; Yokoyama, Takeshi; Hanaoka, Kazuo.
In: Canadian Journal of Anaesthesia, Vol. 45, No. 8, 01.01.1998, p. 789-793.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Liver and renal function after repeated sevoflurane or isoflurane anaesthesia
AU - Nishiyama, Tomoki
AU - Yokoyama, Takeshi
AU - Hanaoka, Kazuo
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Purpose: To compare retrospectively liver and renal function after repeated exposure (twice) to sevoflurane or isoflurane. Methods: Sixty patients were studied for liver and renal function after repeated exposure within 30 to 180 days to sevoflurane (30 patients) or isoflurane (30 patients). Serum concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBil), alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GTP), blood urea nitrogen (BUN) and creatinine (Cr) were measured before and, 1, 3, 7, and 14 days after surgery. Qualitative analyses of urinary protein and glucose were done 1, 3, and 7 days after surgery. Results: The number of patients with abnormal values in AST, ALT and GTP was larger in the isoflurane than in the sevoflurane group. BUN and Cr were within normal range after anaesthesia in either group. Renal excretion of protein and glucose increased one and three days after anaesthesia with no difference between the anaesthetics. None of the variables showed differences between the first and second anaesthesia after either anaesthetic. Conclusion: Repeat exposure to sevoflurane or isoflurane within 30 to 180 clays had no additional risk of increasing serum concentration of liver enzymes or increasing urinary excretion of protein and glucose compared with the first exposure to the same anaesthetic.
AB - Purpose: To compare retrospectively liver and renal function after repeated exposure (twice) to sevoflurane or isoflurane. Methods: Sixty patients were studied for liver and renal function after repeated exposure within 30 to 180 days to sevoflurane (30 patients) or isoflurane (30 patients). Serum concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBil), alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GTP), blood urea nitrogen (BUN) and creatinine (Cr) were measured before and, 1, 3, 7, and 14 days after surgery. Qualitative analyses of urinary protein and glucose were done 1, 3, and 7 days after surgery. Results: The number of patients with abnormal values in AST, ALT and GTP was larger in the isoflurane than in the sevoflurane group. BUN and Cr were within normal range after anaesthesia in either group. Renal excretion of protein and glucose increased one and three days after anaesthesia with no difference between the anaesthetics. None of the variables showed differences between the first and second anaesthesia after either anaesthetic. Conclusion: Repeat exposure to sevoflurane or isoflurane within 30 to 180 clays had no additional risk of increasing serum concentration of liver enzymes or increasing urinary excretion of protein and glucose compared with the first exposure to the same anaesthetic.
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U2 - 10.1007/BF03012151
DO - 10.1007/BF03012151
M3 - Article
C2 - 9793670
AN - SCOPUS:0031771723
VL - 45
SP - 789
EP - 793
JO - Canadian Journal of Anaesthesia
JF - Canadian Journal of Anaesthesia
SN - 0832-610X
IS - 8
ER -