Liver architecture, cell function, and disease

Hiromi Ishibashi, Minoru Nakamura, Atsumasa Komori, Kiyoshi Migita, Shinji Shimoda

Research output: Contribution to journalReview article

85 Citations (Scopus)

Abstract

The liver is an organ consisting of the largest reticulo-endothelial cell network in the body and playing an important role in host defense against invading microorganisms. The organ is comprised of parenchymal cells and many different types of non-parenchymal cells, all of which play a significant role. Even biliary epithelial cells are not only the target in autoimmune liver diseases but also have central role in orchestrating several immune cells involved in both innate and acquired immunity. Tissue damage caused by various agents results in inflammation, necrosis, fibrosis, and, eventually, distortion of normal hepatic architecture, cirrhosis, and functional deterioration.

Original languageEnglish
Pages (from-to)399-409
Number of pages11
JournalSeminars in Immunopathology
Volume31
Issue number3
DOIs
Publication statusPublished - Sep 1 2009

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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