Liver transplantation for cystic fibrosis in adults

Toru Ikegami, Edmund Q. Sanchez, Tadahiro Uemura, Gomathy Narasimhan, Ousama Masannat, Srinath Chinnakotla, Gregory J. McKenna, Henry B. Randall, Marlon F. Levy, Robert M. Goldstein, Goran B. Klintmalm

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose. To expand our knowledge on liver transplantation for cirrhosis associated with cystic fibrosis in adults. Methods. Five patients who underwent a liver transplantation due to cystic fibrosis were reviewed. The outcome of the patients in terms of age, immunosuppression regimen, patient and graft survival, and pre- and post-transplant complications were investigated. Results. Five adult liver transplant patients had cystic fibrosis (0.2%). These included 4 men and 1 woman with a mean age of 31 ± 10, ranging from 22 to 52 years old at the time of transplantation. All patients had lung problems. Four patients had exocrine and two had endocrine pancreatic insufficiency. Two are currently alive with a follow-up of 5.8 years and 4 months after transplantation, respectively. There were three deaths from pulmonary embolism at 4.5 years, myocardial infarction with cyclosporine nephrotoxicity at 10.7 years, and lymphoproliferative disorder at 5 months after transplantation. No deaths occurred from lung infection. Only one patient had postoperative pulmonary infectious complications, which were successfully treated with antibiotics and did not result in mortality. Conclusion. Adult liver transplantation for end-stage liver disease associated with cystic fibrosis offers encouraging results with a rapid general improvement after surgery and it is now considered to be a safe and acceptable treatment for this disease population.

Original languageEnglish
Pages (from-to)26-29
Number of pages4
JournalSurgery today
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

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Cystic Fibrosis
Liver Transplantation
Transplantation
Transplants
Lung
Exocrine Pancreatic Insufficiency
End Stage Liver Disease
Lymphoproliferative Disorders
Graft Survival
Pulmonary Embolism
Liver Cirrhosis
Immunosuppression
Cyclosporine
Myocardial Infarction
Anti-Bacterial Agents
Mortality
Liver
Infection
Population

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Ikegami, T., Sanchez, E. Q., Uemura, T., Narasimhan, G., Masannat, O., Chinnakotla, S., ... Klintmalm, G. B. (2008). Liver transplantation for cystic fibrosis in adults. Surgery today, 38(1), 26-29. https://doi.org/10.1007/s00595-007-3576-7

Liver transplantation for cystic fibrosis in adults. / Ikegami, Toru; Sanchez, Edmund Q.; Uemura, Tadahiro; Narasimhan, Gomathy; Masannat, Ousama; Chinnakotla, Srinath; McKenna, Gregory J.; Randall, Henry B.; Levy, Marlon F.; Goldstein, Robert M.; Klintmalm, Goran B.

In: Surgery today, Vol. 38, No. 1, 01.01.2008, p. 26-29.

Research output: Contribution to journalArticle

Ikegami, T, Sanchez, EQ, Uemura, T, Narasimhan, G, Masannat, O, Chinnakotla, S, McKenna, GJ, Randall, HB, Levy, MF, Goldstein, RM & Klintmalm, GB 2008, 'Liver transplantation for cystic fibrosis in adults', Surgery today, vol. 38, no. 1, pp. 26-29. https://doi.org/10.1007/s00595-007-3576-7
Ikegami T, Sanchez EQ, Uemura T, Narasimhan G, Masannat O, Chinnakotla S et al. Liver transplantation for cystic fibrosis in adults. Surgery today. 2008 Jan 1;38(1):26-29. https://doi.org/10.1007/s00595-007-3576-7
Ikegami, Toru ; Sanchez, Edmund Q. ; Uemura, Tadahiro ; Narasimhan, Gomathy ; Masannat, Ousama ; Chinnakotla, Srinath ; McKenna, Gregory J. ; Randall, Henry B. ; Levy, Marlon F. ; Goldstein, Robert M. ; Klintmalm, Goran B. / Liver transplantation for cystic fibrosis in adults. In: Surgery today. 2008 ; Vol. 38, No. 1. pp. 26-29.
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