Living donor liver transplantation for end-stage liver disease with severe hepatopulmonary syndrome

Report of a case

Takashi Motomura, Toru Ikegami, Yohei Mano, Shigeyuki Nagata, Keishi Sugimachi, Tomoharu Gion, Yuji Soejima, Akinobu Taketomi, Ken Shirabe, Yoshihiko Maehara

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hepatopulmonary syndrome (HPS) is a serious complication of terminal liver disease, which manifests as severe hypoxia without any pulmonary anatomic or functional causes. The precise indications for liver transplantation in patients with severe HPS also remain unclear. A 49-year old woman was referred to our department for investigation and management of liver cirrhosis with severe hypoxia (PaO2, 38 mmHg). A pulmonary perfusion scintigram showed an intrapulmonary shunt ratio of 40%, confirming a diagnosis of severe HPS. She underwent living donor liver transplantation using a right lobe graft donated by her 27-yearold daughter. Her post-transplant graft function was excellent, and her oxygenation recovered slowly but steadily. She was discharged from hospital on posttransplant day 39 with an SpO2 of 94% under 3 l/min of O 2, delivered nasally. Despite the severity of the HPS, her postoperative recovery was smooth after the liver transplant.

Original languageEnglish
Pages (from-to)436-440
Number of pages5
JournalSurgery Today
Volume41
Issue number3
DOIs
Publication statusPublished - Mar 1 2011

Fingerprint

Hepatopulmonary Syndrome
End Stage Liver Disease
Living Donors
Liver Transplantation
Transplants
Lung
Nuclear Family
Liver Cirrhosis
Liver Diseases
Perfusion
Liver

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Living donor liver transplantation for end-stage liver disease with severe hepatopulmonary syndrome : Report of a case. / Motomura, Takashi; Ikegami, Toru; Mano, Yohei; Nagata, Shigeyuki; Sugimachi, Keishi; Gion, Tomoharu; Soejima, Yuji; Taketomi, Akinobu; Shirabe, Ken; Maehara, Yoshihiko.

In: Surgery Today, Vol. 41, No. 3, 01.03.2011, p. 436-440.

Research output: Contribution to journalArticle

Motomura, T, Ikegami, T, Mano, Y, Nagata, S, Sugimachi, K, Gion, T, Soejima, Y, Taketomi, A, Shirabe, K & Maehara, Y 2011, 'Living donor liver transplantation for end-stage liver disease with severe hepatopulmonary syndrome: Report of a case', Surgery Today, vol. 41, no. 3, pp. 436-440. https://doi.org/10.1007/s00595-009-4260-x
Motomura, Takashi ; Ikegami, Toru ; Mano, Yohei ; Nagata, Shigeyuki ; Sugimachi, Keishi ; Gion, Tomoharu ; Soejima, Yuji ; Taketomi, Akinobu ; Shirabe, Ken ; Maehara, Yoshihiko. / Living donor liver transplantation for end-stage liver disease with severe hepatopulmonary syndrome : Report of a case. In: Surgery Today. 2011 ; Vol. 41, No. 3. pp. 436-440.
@article{2164ad91484b4ce6aa488f7629a0f876,
title = "Living donor liver transplantation for end-stage liver disease with severe hepatopulmonary syndrome: Report of a case",
abstract = "Hepatopulmonary syndrome (HPS) is a serious complication of terminal liver disease, which manifests as severe hypoxia without any pulmonary anatomic or functional causes. The precise indications for liver transplantation in patients with severe HPS also remain unclear. A 49-year old woman was referred to our department for investigation and management of liver cirrhosis with severe hypoxia (PaO2, 38 mmHg). A pulmonary perfusion scintigram showed an intrapulmonary shunt ratio of 40{\%}, confirming a diagnosis of severe HPS. She underwent living donor liver transplantation using a right lobe graft donated by her 27-yearold daughter. Her post-transplant graft function was excellent, and her oxygenation recovered slowly but steadily. She was discharged from hospital on posttransplant day 39 with an SpO2 of 94{\%} under 3 l/min of O 2, delivered nasally. Despite the severity of the HPS, her postoperative recovery was smooth after the liver transplant.",
author = "Takashi Motomura and Toru Ikegami and Yohei Mano and Shigeyuki Nagata and Keishi Sugimachi and Tomoharu Gion and Yuji Soejima and Akinobu Taketomi and Ken Shirabe and Yoshihiko Maehara",
year = "2011",
month = "3",
day = "1",
doi = "10.1007/s00595-009-4260-x",
language = "English",
volume = "41",
pages = "436--440",
journal = "Surgery Today",
issn = "0941-1291",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - Living donor liver transplantation for end-stage liver disease with severe hepatopulmonary syndrome

T2 - Report of a case

AU - Motomura, Takashi

AU - Ikegami, Toru

AU - Mano, Yohei

AU - Nagata, Shigeyuki

AU - Sugimachi, Keishi

AU - Gion, Tomoharu

AU - Soejima, Yuji

AU - Taketomi, Akinobu

AU - Shirabe, Ken

AU - Maehara, Yoshihiko

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Hepatopulmonary syndrome (HPS) is a serious complication of terminal liver disease, which manifests as severe hypoxia without any pulmonary anatomic or functional causes. The precise indications for liver transplantation in patients with severe HPS also remain unclear. A 49-year old woman was referred to our department for investigation and management of liver cirrhosis with severe hypoxia (PaO2, 38 mmHg). A pulmonary perfusion scintigram showed an intrapulmonary shunt ratio of 40%, confirming a diagnosis of severe HPS. She underwent living donor liver transplantation using a right lobe graft donated by her 27-yearold daughter. Her post-transplant graft function was excellent, and her oxygenation recovered slowly but steadily. She was discharged from hospital on posttransplant day 39 with an SpO2 of 94% under 3 l/min of O 2, delivered nasally. Despite the severity of the HPS, her postoperative recovery was smooth after the liver transplant.

AB - Hepatopulmonary syndrome (HPS) is a serious complication of terminal liver disease, which manifests as severe hypoxia without any pulmonary anatomic or functional causes. The precise indications for liver transplantation in patients with severe HPS also remain unclear. A 49-year old woman was referred to our department for investigation and management of liver cirrhosis with severe hypoxia (PaO2, 38 mmHg). A pulmonary perfusion scintigram showed an intrapulmonary shunt ratio of 40%, confirming a diagnosis of severe HPS. She underwent living donor liver transplantation using a right lobe graft donated by her 27-yearold daughter. Her post-transplant graft function was excellent, and her oxygenation recovered slowly but steadily. She was discharged from hospital on posttransplant day 39 with an SpO2 of 94% under 3 l/min of O 2, delivered nasally. Despite the severity of the HPS, her postoperative recovery was smooth after the liver transplant.

UR - http://www.scopus.com/inward/record.url?scp=79955935546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955935546&partnerID=8YFLogxK

U2 - 10.1007/s00595-009-4260-x

DO - 10.1007/s00595-009-4260-x

M3 - Article

VL - 41

SP - 436

EP - 440

JO - Surgery Today

JF - Surgery Today

SN - 0941-1291

IS - 3

ER -