Living donor liver transplantation in patients older than 60 years

Tomoharu Yoshizumi, Ken Shirabe, Yuji Soejima, Akinobu Taketomi, Natsumi Yamashita, Toru Ikegami, Hideaki Uchiyama, Hiroto Kayashima, Mizuki Ninomiya, Yoshihiko Maehara

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Background. Living donor liver transplantation (LDLT) has been performed in adult patients. However, there are a few reports on how recipient age affects the outcome of LDLT. This study assessed LDLT outcome in patients aged 60 years or older. Methods. A total of 267 patients were enrolled and classified into two groups: those younger than 60 years (younger group, n=210) and those aged 60 years or older (older group, n=57). The 6-month and 1-, 3-, and 5-year patient survivals and the incidence of complications were compared. Multivariate analysis was performed to identify the risk factors. Results. Fifty-five of 57 (96.5%) donors in the older group were younger than 50 years (range 25-47 years), whereas only 177 of 210 (84.3%) donors in the younger group were younger than 50 years (P<0.0001). The 6-month and 1-, 3-, and 5-year patient survival rates of the older group were 92.9%, 85.3%, 72.7%, and 70.3%, respectively, whereas those of the younger group were 87.4%, 85.8%, 80.2%, and 78.2%, respectively. Neither difference was significant. A multivariate analysis revealed that the presence of diabetes, lack of hepatocellular carcinoma, and Model for End-Stage Liver Disease (MELD) Score more than or equal to 20 were independent risk factors for survival less than 1 year after LDLT (P=0.0003, P=0.014, and P=0.041, respectively). Another multivariate analysis revealed that the lack of consanguinity, MELD Score more than or equal to 20, and male recipient were independent risk factors for death 1 year or more after LDLT (P=0.004, P=0.005, and P=0.015, respectively). Conclusion. Recipient age did not affect LDLT outcome when patients with MELD Score less than 20 received grafts from consanguineous donors.

Original languageEnglish
Pages (from-to)433-437
Number of pages5
JournalTransplantation
Volume90
Issue number4
DOIs
Publication statusPublished - Aug 27 2010

All Science Journal Classification (ASJC) codes

  • Transplantation

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