Load dependence of ventricular performance explained by changes in calcium myofilament interactions

Juichiro Shimizu, Koji Todaka, Daniel Burkhoff

Research output: Contribution to journalArticle

Abstract

A study was carried out to test whether a 4-state biochemical model with length dependent rate constants could explain contractile behavior of ejecting hearts. Studies were performed in isolated, physiologically afterloaded canine hearts and intracellular calcium transients measured with macroinjected aequorin. Results help bridge the gap between basic molecular research and whole organ physiology.

Original languageEnglish
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
Publication statusPublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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