Lobar lung transplantation

A relevant surgical option in the current era of lung allocation score

Norihisa Shigemura, Jonathan D'Cunha, Jay K. Bhama, Akira Shiose, Ashraf Abou El Ela, Amy Hackmann, Diana Zaldonis, Yoshiya Toyoda, Joseph M. Pilewski, James D. Luketich, Christian A. Bermudez

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: With the implementation of the lung allocation score (LAS) system, an increased number of critically ill patients are considered for transplantation. However, LAS does not take size matching between donor and recipient lungs into consideration. Mortality on the waiting list is high (as high as 25%) for short-stature patients and for patients with restrictive lung disease. Here, we review our experience using cadaveric lobar lung transplantation as a surgical option in an attempt to decrease mortality while waiting. Methods: We retrospectively reviewed patients with end-stage lung diseases and an LAS greater than 70 who underwent cadaveric lobar lung transplantation between 2010 and 2012 (n = 25) at our institution, a high-volume lung transplant center. Anatomic lobectomy was performed on all donor lungs before double lung transplantation. Results: Median LAS was 85.6 (range, 72 to 94). Average waiting time after the patients' LAS was updated to greater than 70 was 10 days (range, 1 to 41). There were 2 in-hospital deaths. The 90-day and 1-year survivals were 88% and 76%, respectively. Patient major comorbidities included severe primary graft dysfunction requiring postoperative extracorporeal membrane oxygenation (7 patients), acute renal insufficiency (4 patients), and bleeding requiring reoperation (4 patients). No technical problems were identified, and repeated bronchoscopy demonstrated satisfactory healing of the bronchial stump after lobectomy. The average posttransplant peak for forced expiratory volume in 1 second was 85%. Conclusions: Our initial experience supports the option of lobar lung transplantation for critically ill patients whose opportunities for transplant are limited by their stature. Long-term functional studies are warranted.

Original languageEnglish
Pages (from-to)451-456
Number of pages6
JournalAnnals of Thoracic Surgery
Volume96
Issue number2
DOIs
Publication statusPublished - Aug 1 2013
Externally publishedYes

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Lung Transplantation
Lung
Critical Illness
Lung Diseases
Primary Graft Dysfunction
Tissue Donors
Transplants
Extracorporeal Membrane Oxygenation
Waiting Lists
Mortality
Forced Expiratory Volume
Bronchoscopy
Reoperation
Acute Kidney Injury
Comorbidity
Transplantation
Hemorrhage
Survival

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Lobar lung transplantation : A relevant surgical option in the current era of lung allocation score. / Shigemura, Norihisa; D'Cunha, Jonathan; Bhama, Jay K.; Shiose, Akira; Abou El Ela, Ashraf; Hackmann, Amy; Zaldonis, Diana; Toyoda, Yoshiya; Pilewski, Joseph M.; Luketich, James D.; Bermudez, Christian A.

In: Annals of Thoracic Surgery, Vol. 96, No. 2, 01.08.2013, p. 451-456.

Research output: Contribution to journalArticle

Shigemura, N, D'Cunha, J, Bhama, JK, Shiose, A, Abou El Ela, A, Hackmann, A, Zaldonis, D, Toyoda, Y, Pilewski, JM, Luketich, JD & Bermudez, CA 2013, 'Lobar lung transplantation: A relevant surgical option in the current era of lung allocation score', Annals of Thoracic Surgery, vol. 96, no. 2, pp. 451-456. https://doi.org/10.1016/j.athoracsur.2013.04.030
Shigemura, Norihisa ; D'Cunha, Jonathan ; Bhama, Jay K. ; Shiose, Akira ; Abou El Ela, Ashraf ; Hackmann, Amy ; Zaldonis, Diana ; Toyoda, Yoshiya ; Pilewski, Joseph M. ; Luketich, James D. ; Bermudez, Christian A. / Lobar lung transplantation : A relevant surgical option in the current era of lung allocation score. In: Annals of Thoracic Surgery. 2013 ; Vol. 96, No. 2. pp. 451-456.
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abstract = "Background: With the implementation of the lung allocation score (LAS) system, an increased number of critically ill patients are considered for transplantation. However, LAS does not take size matching between donor and recipient lungs into consideration. Mortality on the waiting list is high (as high as 25{\%}) for short-stature patients and for patients with restrictive lung disease. Here, we review our experience using cadaveric lobar lung transplantation as a surgical option in an attempt to decrease mortality while waiting. Methods: We retrospectively reviewed patients with end-stage lung diseases and an LAS greater than 70 who underwent cadaveric lobar lung transplantation between 2010 and 2012 (n = 25) at our institution, a high-volume lung transplant center. Anatomic lobectomy was performed on all donor lungs before double lung transplantation. Results: Median LAS was 85.6 (range, 72 to 94). Average waiting time after the patients' LAS was updated to greater than 70 was 10 days (range, 1 to 41). There were 2 in-hospital deaths. The 90-day and 1-year survivals were 88{\%} and 76{\%}, respectively. Patient major comorbidities included severe primary graft dysfunction requiring postoperative extracorporeal membrane oxygenation (7 patients), acute renal insufficiency (4 patients), and bleeding requiring reoperation (4 patients). No technical problems were identified, and repeated bronchoscopy demonstrated satisfactory healing of the bronchial stump after lobectomy. The average posttransplant peak for forced expiratory volume in 1 second was 85{\%}. Conclusions: Our initial experience supports the option of lobar lung transplantation for critically ill patients whose opportunities for transplant are limited by their stature. Long-term functional studies are warranted.",
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AU - D'Cunha, Jonathan

AU - Bhama, Jay K.

AU - Shiose, Akira

AU - Abou El Ela, Ashraf

AU - Hackmann, Amy

AU - Zaldonis, Diana

AU - Toyoda, Yoshiya

AU - Pilewski, Joseph M.

AU - Luketich, James D.

AU - Bermudez, Christian A.

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N2 - Background: With the implementation of the lung allocation score (LAS) system, an increased number of critically ill patients are considered for transplantation. However, LAS does not take size matching between donor and recipient lungs into consideration. Mortality on the waiting list is high (as high as 25%) for short-stature patients and for patients with restrictive lung disease. Here, we review our experience using cadaveric lobar lung transplantation as a surgical option in an attempt to decrease mortality while waiting. Methods: We retrospectively reviewed patients with end-stage lung diseases and an LAS greater than 70 who underwent cadaveric lobar lung transplantation between 2010 and 2012 (n = 25) at our institution, a high-volume lung transplant center. Anatomic lobectomy was performed on all donor lungs before double lung transplantation. Results: Median LAS was 85.6 (range, 72 to 94). Average waiting time after the patients' LAS was updated to greater than 70 was 10 days (range, 1 to 41). There were 2 in-hospital deaths. The 90-day and 1-year survivals were 88% and 76%, respectively. Patient major comorbidities included severe primary graft dysfunction requiring postoperative extracorporeal membrane oxygenation (7 patients), acute renal insufficiency (4 patients), and bleeding requiring reoperation (4 patients). No technical problems were identified, and repeated bronchoscopy demonstrated satisfactory healing of the bronchial stump after lobectomy. The average posttransplant peak for forced expiratory volume in 1 second was 85%. Conclusions: Our initial experience supports the option of lobar lung transplantation for critically ill patients whose opportunities for transplant are limited by their stature. Long-term functional studies are warranted.

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