Local hyperthermia enhances thrombosis in aneurysms containing platinum coils

Osamu Suzuki, S. Miyachi, T. Okamoto, Akira Ito, M. Shinkai, H. Honda, T. Kobayashi, M. Negoro, J. Yoshida

Research output: Contribution to journalArticle

Abstract

Despite recent technical advances in embolization of cerebral aneurysms with platinum coils, some aneurysms eventually resulted in incomplete packing with remnant neck or dome filling. Such a situation with a remaining inflow zone may pose a risk of rupture and subsequent regrowth. Metals characteristically generate heat under high-frequency alternating magnetic fields (AMF). We used this property to induce local hyperthermia and promote thrombogenesis in incompletely packed aneurysms. Glass model aneurysms packed with coils were subjected to AMF to investigate the correlation between weight of platinum and temperature elevation and the correlation between flow rates of water through the model and temperature elevation. Next, activated coagulation time (ACT) of blood obtained from dogs was studied at various temperatures. Finally, side-wall aneurysms created in the canine carotid artery using a venous patch were packed with platinum coils. Change in temperature and angiographic changes were investigated after AMF application. In the glass model, the weight of platinum was correlated with elevation of temperature, and a negative logarithmic correlation was evident between flow rate and elevation of temperature. Elevation of blood sample temperature tended to shorten ACT In canine carotid aneurysms, elevation of intra-aneurysmal temperature was confirmed and sufficient elevation of temperature was found to promote angiographically evident thrombogenesis of the remnant space after AMF application. Local hyperthermia may be useful in completing luminal obliteration of aneurysms after coil embolization. It may particularly useful for ruptured aneurysms to prevent the early rerupture.

Original languageEnglish
Pages (from-to)203-211
Number of pages9
JournalInterventional Neuroradiology
Volume10
Issue number3
Publication statusPublished - Sep 1 2004

Fingerprint

Induced Hyperthermia
Platinum
Aneurysm
Thrombosis
Temperature
Magnetic Fields
Glass
Canidae
Weights and Measures
Ruptured Aneurysm
Intracranial Aneurysm
Blood Coagulation
Carotid Arteries
Rupture
Neck
Hot Temperature
Metals
Dogs
Water

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Suzuki, O., Miyachi, S., Okamoto, T., Ito, A., Shinkai, M., Honda, H., ... Yoshida, J. (2004). Local hyperthermia enhances thrombosis in aneurysms containing platinum coils. Interventional Neuroradiology, 10(3), 203-211.

Local hyperthermia enhances thrombosis in aneurysms containing platinum coils. / Suzuki, Osamu; Miyachi, S.; Okamoto, T.; Ito, Akira; Shinkai, M.; Honda, H.; Kobayashi, T.; Negoro, M.; Yoshida, J.

In: Interventional Neuroradiology, Vol. 10, No. 3, 01.09.2004, p. 203-211.

Research output: Contribution to journalArticle

Suzuki, O, Miyachi, S, Okamoto, T, Ito, A, Shinkai, M, Honda, H, Kobayashi, T, Negoro, M & Yoshida, J 2004, 'Local hyperthermia enhances thrombosis in aneurysms containing platinum coils', Interventional Neuroradiology, vol. 10, no. 3, pp. 203-211.
Suzuki O, Miyachi S, Okamoto T, Ito A, Shinkai M, Honda H et al. Local hyperthermia enhances thrombosis in aneurysms containing platinum coils. Interventional Neuroradiology. 2004 Sep 1;10(3):203-211.
Suzuki, Osamu ; Miyachi, S. ; Okamoto, T. ; Ito, Akira ; Shinkai, M. ; Honda, H. ; Kobayashi, T. ; Negoro, M. ; Yoshida, J. / Local hyperthermia enhances thrombosis in aneurysms containing platinum coils. In: Interventional Neuroradiology. 2004 ; Vol. 10, No. 3. pp. 203-211.
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