Localizations of epidermal growth factor receptor and proliferating cell nuclear antigen during corneal wound healing

Toshinori Murata, Tatsuro Ishibashi, Hajime Inomata

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Abstract

The localization of epidermal growth factor receptor and proliferating cell nuclear antigen was demonstrated immunohistochemical to be similar in the corneal, limbal, and bulbar conjunctival epithelium, i.e., located adjacent to the artificially made corneal epithelial defect. In the course of regeneration of the corneal epithelium soon after the wounding, both epidermal growth factor receptor and proliferating cell nuclear antigen were expressed in the epithelial cells in the limbal area adjacent to the epithelial defect. After the defect was covered with several layers of regenerated epithelium, the main site of the expression of epidermal growth factor receptor and proliferating cell nuclear antigen moved to the basal layer of regenerated epithelium. The present study indicated that epidermal growth factor receptor, as expressed on the epithelial cell surface, can be considered to play an important role in epithelial cell proliferation, which is an indispensable process in corneal wound healing.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume231
Issue number2
DOIs
Publication statusPublished - Feb 1 1993

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All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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