Locally synchronized synaptic inputs

Naoya Takahashi, Kazuo Kitamura, Naoki Matsuo, Mark Mayford, Masanobu Kano, Norio Matsuki, Yuji Ikegaya

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Synaptic inputs on dendrites are nonlinearly converted to action potential outputs, yet the spatiotemporal patterns of dendritic activation remain to be elucidated at single-synapse resolution. In rodents, we optically imaged synaptic activities from hundreds of dendritic spines in hippocampal and neocortical pyramidal neurons ex vivo and in vivo. Adjacent spines were frequently synchronized in spontaneously active networks, thereby forming dendritic foci that received locally convergent inputs from presynaptic cell assemblies. This precise subcellular geometry manifested itself during N-methyl-D-aspartate receptor - dependent circuit remodeling. Thus, clustered synaptic plasticity is innately programmed to compartmentalize correlated inputs along dendrites and may reify nonlinear synaptic integration.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalScience
Volume335
Issue number6066
DOIs
Publication statusPublished - Jan 20 2012
Externally publishedYes

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Dendrites
Dendritic Spines
Neuronal Plasticity
Pyramidal Cells
N-Methyl-D-Aspartate Receptors
Synapses
Action Potentials
Rodentia
Spine

All Science Journal Classification (ASJC) codes

  • General

Cite this

Takahashi, N., Kitamura, K., Matsuo, N., Mayford, M., Kano, M., Matsuki, N., & Ikegaya, Y. (2012). Locally synchronized synaptic inputs. Science, 335(6066), 353-356. https://doi.org/10.1126/science.1210362

Locally synchronized synaptic inputs. / Takahashi, Naoya; Kitamura, Kazuo; Matsuo, Naoki; Mayford, Mark; Kano, Masanobu; Matsuki, Norio; Ikegaya, Yuji.

In: Science, Vol. 335, No. 6066, 20.01.2012, p. 353-356.

Research output: Contribution to journalArticle

Takahashi, N, Kitamura, K, Matsuo, N, Mayford, M, Kano, M, Matsuki, N & Ikegaya, Y 2012, 'Locally synchronized synaptic inputs', Science, vol. 335, no. 6066, pp. 353-356. https://doi.org/10.1126/science.1210362
Takahashi N, Kitamura K, Matsuo N, Mayford M, Kano M, Matsuki N et al. Locally synchronized synaptic inputs. Science. 2012 Jan 20;335(6066):353-356. https://doi.org/10.1126/science.1210362
Takahashi, Naoya ; Kitamura, Kazuo ; Matsuo, Naoki ; Mayford, Mark ; Kano, Masanobu ; Matsuki, Norio ; Ikegaya, Yuji. / Locally synchronized synaptic inputs. In: Science. 2012 ; Vol. 335, No. 6066. pp. 353-356.
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