Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain

Toshihide Kuroki, Takashi Matsumoto, Makoto Hirano, Hiroshi Kagoshima, Hiroshi Yao, Hideyuki Uchimura, Kaoru Nakamura, Tatsuo Nakahara

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The effect of systemically administrated cholecystokinin analog, caerulein, on monoaminergic neurons was examined in discrete regions of rat brain. A single injection of caerulein (400 μg/kg, i.p.) significantly elevated 5-hydroxyindoleacetic acid (5HIAA) levels in the prefrontal cortex lateral field, nucleus accumbens, tuberculum olfactorium and striatum after 2 hours, together with a significant increase in striatal serotonin (5HT). Moreover, the time-course study showed that the caerulein-induced increase in both 5HIAA and 5HT levels lasted even for 24 hours, and their levels tended to recover to the control values gradually. This time-dependent change was not found in the other monoamines and their metabolites. These results suggest a long-lasting action of caerulein on 5HT neurons in specific regions of rat brain.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
Issue number2
Publication statusPublished - Jan 1 1987
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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