Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain

Toshihide Kuroki, Takashi Matsumoto, Makoto Hirano, Hiroshi Kagoshima, Hiroshi Yao, Hideyuki Uchimura, Kaoru Nakamura, Tatsuo Nakahara

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The effect of systemically administrated cholecystokinin analog, caerulein, on monoaminergic neurons was examined in discrete regions of rat brain. A single injection of caerulein (400 μg/kg, i.p.) significantly elevated 5-hydroxyindoleacetic acid (5HIAA) levels in the prefrontal cortex lateral field, nucleus accumbens, tuberculum olfactorium and striatum after 2 hours, together with a significant increase in striatal serotonin (5HT). Moreover, the time-course study showed that the caerulein-induced increase in both 5HIAA and 5HT levels lasted even for 24 hours, and their levels tended to recover to the control values gradually. This time-dependent change was not found in the other monoamines and their metabolites. These results suggest a long-lasting action of caerulein on 5HT neurons in specific regions of rat brain.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalNeuropeptides
Volume9
Issue number2
DOIs
Publication statusPublished - Jan 1 1987
Externally publishedYes

Fingerprint

Ceruletide
Hydroxyindoleacetic Acid
Brain
Neurons
Corpus Striatum
Cholecystokinin
Nucleus Accumbens
Prefrontal Cortex
Serotonin
Injections

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Cite this

Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain. / Kuroki, Toshihide; Matsumoto, Takashi; Hirano, Makoto; Kagoshima, Hiroshi; Yao, Hiroshi; Uchimura, Hideyuki; Nakamura, Kaoru; Nakahara, Tatsuo.

In: Neuropeptides, Vol. 9, No. 2, 01.01.1987, p. 169-176.

Research output: Contribution to journalArticle

Kuroki, T, Matsumoto, T, Hirano, M, Kagoshima, H, Yao, H, Uchimura, H, Nakamura, K & Nakahara, T 1987, 'Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain', Neuropeptides, vol. 9, no. 2, pp. 169-176. https://doi.org/10.1016/0143-4179(87)90055-2
Kuroki, Toshihide ; Matsumoto, Takashi ; Hirano, Makoto ; Kagoshima, Hiroshi ; Yao, Hiroshi ; Uchimura, Hideyuki ; Nakamura, Kaoru ; Nakahara, Tatsuo. / Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain. In: Neuropeptides. 1987 ; Vol. 9, No. 2. pp. 169-176.
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