Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain

Toshihide Kuroki; Takashi Matsumoto; Makoto Hirano; Hiroshi Kagoshima; Hiroshi Yao; Hideyuki Uchimura; Kaoru Nakamura; Tatsuo Nakahara

doi:10.1016/0143-4179(87)90055-2

Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain

Toshihide Kuroki, Takashi Matsumoto, Makoto Hirano, Hiroshi Kagoshima, Hiroshi Yao, Hideyuki Uchimura, Kaoru Nakamura, Tatsuo Nakahara

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The effect of systemically administrated cholecystokinin analog, caerulein, on monoaminergic neurons was examined in discrete regions of rat brain. A single injection of caerulein (400 μg/kg, i.p.) significantly elevated 5-hydroxyindoleacetic acid (5HIAA) levels in the prefrontal cortex lateral field, nucleus accumbens, tuberculum olfactorium and striatum after 2 hours, together with a significant increase in striatal serotonin (5HT). Moreover, the time-course study showed that the caerulein-induced increase in both 5HIAA and 5HT levels lasted even for 24 hours, and their levels tended to recover to the control values gradually. This time-dependent change was not found in the other monoamines and their metabolites. These results suggest a long-lasting action of caerulein on 5HT neurons in specific regions of rat brain.

Original language	English
Pages (from-to)	169-176
Number of pages	8
Journal	Neuropeptides
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/0143-4179(87)90055-2
Publication status	Published - Jan 1 1987
Externally published	Yes

All Science Journal Classification (ASJC) codes

Endocrinology
Neurology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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10.1016/0143-4179(87)90055-2

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title = "Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain",

abstract = "The effect of systemically administrated cholecystokinin analog, caerulein, on monoaminergic neurons was examined in discrete regions of rat brain. A single injection of caerulein (400 μg/kg, i.p.) significantly elevated 5-hydroxyindoleacetic acid (5HIAA) levels in the prefrontal cortex lateral field, nucleus accumbens, tuberculum olfactorium and striatum after 2 hours, together with a significant increase in striatal serotonin (5HT). Moreover, the time-course study showed that the caerulein-induced increase in both 5HIAA and 5HT levels lasted even for 24 hours, and their levels tended to recover to the control values gradually. This time-dependent change was not found in the other monoamines and their metabolites. These results suggest a long-lasting action of caerulein on 5HT neurons in specific regions of rat brain.",

author = "Toshihide Kuroki and Takashi Matsumoto and Makoto Hirano and Hiroshi Kagoshima and Hiroshi Yao and Hideyuki Uchimura and Kaoru Nakamura and Tatsuo Nakahara",

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doi = "10.1016/0143-4179(87)90055-2",

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T1 - Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain

AU - Kuroki, Toshihide

AU - Matsumoto, Takashi

AU - Hirano, Makoto

AU - Kagoshima, Hiroshi

AU - Yao, Hiroshi

AU - Uchimura, Hideyuki

AU - Nakamura, Kaoru

AU - Nakahara, Tatsuo

PY - 1987/1/1

Y1 - 1987/1/1

N2 - The effect of systemically administrated cholecystokinin analog, caerulein, on monoaminergic neurons was examined in discrete regions of rat brain. A single injection of caerulein (400 μg/kg, i.p.) significantly elevated 5-hydroxyindoleacetic acid (5HIAA) levels in the prefrontal cortex lateral field, nucleus accumbens, tuberculum olfactorium and striatum after 2 hours, together with a significant increase in striatal serotonin (5HT). Moreover, the time-course study showed that the caerulein-induced increase in both 5HIAA and 5HT levels lasted even for 24 hours, and their levels tended to recover to the control values gradually. This time-dependent change was not found in the other monoamines and their metabolites. These results suggest a long-lasting action of caerulein on 5HT neurons in specific regions of rat brain.

AB - The effect of systemically administrated cholecystokinin analog, caerulein, on monoaminergic neurons was examined in discrete regions of rat brain. A single injection of caerulein (400 μg/kg, i.p.) significantly elevated 5-hydroxyindoleacetic acid (5HIAA) levels in the prefrontal cortex lateral field, nucleus accumbens, tuberculum olfactorium and striatum after 2 hours, together with a significant increase in striatal serotonin (5HT). Moreover, the time-course study showed that the caerulein-induced increase in both 5HIAA and 5HT levels lasted even for 24 hours, and their levels tended to recover to the control values gradually. This time-dependent change was not found in the other monoamines and their metabolites. These results suggest a long-lasting action of caerulein on 5HT neurons in specific regions of rat brain.

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Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain

Abstract

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