Long-term down-regulation of GABA decreases orientation selectivity without affecting direction selectivity in mouse primary visual cortex

Kenta M. Hagihara, Kenichi Oki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Inhibitory interneurons play important roles in the development of brain functions. In the visual cortex, functional maturation of inhibitory interneurons is essential for ocular dominance plasticity. However, roles of inhibitory interneurons in the development of orientation and direction selectivity, fundamental properties of primary visual cortex, are less understood. We examined orientation and direction selectivity of neurons in GAD67-GFP (Δneo) mice, in which expression of GABA in the brain is decreased in the newborn. We used in vivo two-photon calcium imaging to examine visual response of neurons in these mice and found that long-term decrease of GABA led to increase of response amplitude to non-preferred orientation of visual stimuli, which decreased orientation selectivity. In contrast, direction selectivity was not affected. These results suggest that orientation selectivity is decreased in mice with GABA down-regulation during development.

Original languageEnglish
JournalFrontiers in Neural Circuits
Issue numberFEBRUARY 2013
DOIs
Publication statusPublished - Feb 6 2013

Fingerprint

Interneurons
Visual Cortex
gamma-Aminobutyric Acid
Down-Regulation
ocular Dominance
Neurons
Brain
Photons
Calcium
Direction compound

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience
  • Sensory Systems
  • Cognitive Neuroscience

Cite this

Long-term down-regulation of GABA decreases orientation selectivity without affecting direction selectivity in mouse primary visual cortex. / Hagihara, Kenta M.; Oki, Kenichi.

In: Frontiers in Neural Circuits, No. FEBRUARY 2013, 06.02.2013.

Research output: Contribution to journalArticle

@article{d5b50df8a553493690af5ca5ee240f84,
title = "Long-term down-regulation of GABA decreases orientation selectivity without affecting direction selectivity in mouse primary visual cortex",
abstract = "Inhibitory interneurons play important roles in the development of brain functions. In the visual cortex, functional maturation of inhibitory interneurons is essential for ocular dominance plasticity. However, roles of inhibitory interneurons in the development of orientation and direction selectivity, fundamental properties of primary visual cortex, are less understood. We examined orientation and direction selectivity of neurons in GAD67-GFP (Δneo) mice, in which expression of GABA in the brain is decreased in the newborn. We used in vivo two-photon calcium imaging to examine visual response of neurons in these mice and found that long-term decrease of GABA led to increase of response amplitude to non-preferred orientation of visual stimuli, which decreased orientation selectivity. In contrast, direction selectivity was not affected. These results suggest that orientation selectivity is decreased in mice with GABA down-regulation during development.",
author = "Hagihara, {Kenta M.} and Kenichi Oki",
year = "2013",
month = "2",
day = "6",
doi = "10.3389/fncir.2013.00028",
language = "English",
journal = "Frontiers in Neural Circuits",
issn = "1662-5110",
publisher = "Frontiers Research Foundation",
number = "FEBRUARY 2013",

}

TY - JOUR

T1 - Long-term down-regulation of GABA decreases orientation selectivity without affecting direction selectivity in mouse primary visual cortex

AU - Hagihara, Kenta M.

AU - Oki, Kenichi

PY - 2013/2/6

Y1 - 2013/2/6

N2 - Inhibitory interneurons play important roles in the development of brain functions. In the visual cortex, functional maturation of inhibitory interneurons is essential for ocular dominance plasticity. However, roles of inhibitory interneurons in the development of orientation and direction selectivity, fundamental properties of primary visual cortex, are less understood. We examined orientation and direction selectivity of neurons in GAD67-GFP (Δneo) mice, in which expression of GABA in the brain is decreased in the newborn. We used in vivo two-photon calcium imaging to examine visual response of neurons in these mice and found that long-term decrease of GABA led to increase of response amplitude to non-preferred orientation of visual stimuli, which decreased orientation selectivity. In contrast, direction selectivity was not affected. These results suggest that orientation selectivity is decreased in mice with GABA down-regulation during development.

AB - Inhibitory interneurons play important roles in the development of brain functions. In the visual cortex, functional maturation of inhibitory interneurons is essential for ocular dominance plasticity. However, roles of inhibitory interneurons in the development of orientation and direction selectivity, fundamental properties of primary visual cortex, are less understood. We examined orientation and direction selectivity of neurons in GAD67-GFP (Δneo) mice, in which expression of GABA in the brain is decreased in the newborn. We used in vivo two-photon calcium imaging to examine visual response of neurons in these mice and found that long-term decrease of GABA led to increase of response amplitude to non-preferred orientation of visual stimuli, which decreased orientation selectivity. In contrast, direction selectivity was not affected. These results suggest that orientation selectivity is decreased in mice with GABA down-regulation during development.

UR - http://www.scopus.com/inward/record.url?scp=84873715539&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873715539&partnerID=8YFLogxK

U2 - 10.3389/fncir.2013.00028

DO - 10.3389/fncir.2013.00028

M3 - Article

JO - Frontiers in Neural Circuits

JF - Frontiers in Neural Circuits

SN - 1662-5110

IS - FEBRUARY 2013

ER -