Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer

Yuji Maehata, Shotaro Nakamura, Kiyoshi Fujisawa, Motohiro Esaki, Tomohiko Moriyama, Kouichi Asano, Yuta Fuyuno, Kan Yamaguchi, Issei Egashira, Hyonji Kim, Motonobu Kanda, Minako Hirahashi, Takayuki Matsumoto

Research output: Contribution to journalArticle

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Abstract

A prospective, randomized trial proved that Helicobacter pylori eradication significantly reduces the incidence of metachronous gastric cancer during a 3-year follow-up. To investigate the long-term effect of H pylori eradication on the incidence of metachronous gastric cancer after endoscopic resection of early gastric cancer. Retrospective, multicenter study. Kyushu University Hospital and 6 other hospitals in Fukuoka Prefecture, Japan. Follow-up data for 268 H pyloripositive patients who had undergone endoscopic resection of early gastric cancer were retrospectively investigated. A total of 177 patients underwent successful H pylori eradication (eradicated group), whereas 91 had persistent H pylori infection (persistent group). The incidence of metachronous gastric cancer was compared in these 2 groups. When the follow-up period was censored at 5 years, the incidence rate in the eradicated group was lower than that observed in the persistent group (P =.007). During the overall follow-up period ranging from 1.1 to 11.1 years (median 3.0 years), metachronous gastric cancer developed in 13 patients (14.3%) in the persistent group and in 15 patients (8.5%) in the eradicated group (P =.262, log-rank test). Based on a multivariate logistic regression analysis, baseline severe mucosal atrophy and a follow-up of more than 5 years were found to be independent risk factors for the development of metachronous gastric cancer. Retrospective study. H pylori eradication does not reduce the incidence of metachronous gastric cancer. H pylori eradication should be performed before the progression of gastric mucosal atrophy.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalGastrointestinal endoscopy
Volume75
Issue number1
DOIs
Publication statusPublished - Jan 1 2012

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Helicobacter pylori
Stomach Neoplasms
Pylorus
Incidence
Atrophy
Retrospective Studies
Multicenter Studies
Stomach
Japan
Logistic Models
Regression Analysis
Infection

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer. / Maehata, Yuji; Nakamura, Shotaro; Fujisawa, Kiyoshi; Esaki, Motohiro; Moriyama, Tomohiko; Asano, Kouichi; Fuyuno, Yuta; Yamaguchi, Kan; Egashira, Issei; Kim, Hyonji; Kanda, Motonobu; Hirahashi, Minako; Matsumoto, Takayuki.

In: Gastrointestinal endoscopy, Vol. 75, No. 1, 01.01.2012, p. 39-46.

Research output: Contribution to journalArticle

Maehata, Y, Nakamura, S, Fujisawa, K, Esaki, M, Moriyama, T, Asano, K, Fuyuno, Y, Yamaguchi, K, Egashira, I, Kim, H, Kanda, M, Hirahashi, M & Matsumoto, T 2012, 'Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer', Gastrointestinal endoscopy, vol. 75, no. 1, pp. 39-46. https://doi.org/10.1016/j.gie.2011.08.030
Maehata, Yuji ; Nakamura, Shotaro ; Fujisawa, Kiyoshi ; Esaki, Motohiro ; Moriyama, Tomohiko ; Asano, Kouichi ; Fuyuno, Yuta ; Yamaguchi, Kan ; Egashira, Issei ; Kim, Hyonji ; Kanda, Motonobu ; Hirahashi, Minako ; Matsumoto, Takayuki. / Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer. In: Gastrointestinal endoscopy. 2012 ; Vol. 75, No. 1. pp. 39-46.
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