Long-term effects of infrasternal mediastinoscopic thymectomy in myasthenia gravis

Hiroyuki Murai, Akihiko Uchiyama, Feng Jun Mei, Masayuki Kojima, Jun-Ichi Kira

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Endoscopic thymectomy is commonly used for treatment of myasthenia gravis (MG) patients due to its relatively low invasiveness. However, the long-term effects of endoscopic thymectomy have not been fully evaluated. Objective: To assess the long-term effects of extended infrasternal mediastinoscopic thymectomy (IMT) in MG patients and compare them with those of extended transsternal thymectomy (TT). Methods: Among 24 MG patients without thymoma who underwent thymectomy in our Institute between January 1997 and December 2000, 14 patients who received IMT and 10 who received TT were enrolled in the present study. Quantitative myasthenia gravis (QMG) score and anti-acetylcholine receptor antibody (anti-AChR) titers were evaluated before and at five years after surgery. Results: After five years, QMG scores were reduced from 6.6 to 1.8 (p < 0.01) in the IMT group, and from 7.6 to 2.7 (p < 0.01) in the TT group. The anti-AChR titers were reduced from 75.2 to 40.1 (p = 0.027) in the IMT group, and from 224 to 61.3 (p = 0.020) in the TT group. Conclusion: These data suggest that the long-term therapeutic effect of IMT is equivalent to TT, and is thus suitable for the treatment of MG patients.

Original languageEnglish
Pages (from-to)185-187
Number of pages3
JournalJournal of the Neurological Sciences
Volume287
Issue number1-2
DOIs
Publication statusPublished - Dec 15 2009

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Thymectomy
Myasthenia Gravis
Cholinergic Receptors
Thymoma
Antibodies
Therapeutic Uses

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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Long-term effects of infrasternal mediastinoscopic thymectomy in myasthenia gravis. / Murai, Hiroyuki; Uchiyama, Akihiko; Mei, Feng Jun; Kojima, Masayuki; Kira, Jun-Ichi.

In: Journal of the Neurological Sciences, Vol. 287, No. 1-2, 15.12.2009, p. 185-187.

Research output: Contribution to journalArticle

Murai, Hiroyuki ; Uchiyama, Akihiko ; Mei, Feng Jun ; Kojima, Masayuki ; Kira, Jun-Ichi. / Long-term effects of infrasternal mediastinoscopic thymectomy in myasthenia gravis. In: Journal of the Neurological Sciences. 2009 ; Vol. 287, No. 1-2. pp. 185-187.
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