Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core–Shell Nanowires

Teppei Araki, Fumiaki Yoshida, Takafumi Uemura, Yuki Noda, Shusuke Yoshimoto, Taro Kaiju, Takafumi Suzuki, Hiroki Hamanaka, Kousuke Baba, Hideki Hayakawa, Taiki Yabumoto, Hideki Mochizuki, Shingo Kobayashi, Masaru Tanaka, Masayuki Hirata, Tsuyoshi Sekitani

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Neural interfaces enabling light transmittance rely on optogenetics to control and monitor specific neural activity, thereby facilitating deeper understanding of intractable diseases. This study reports the material strategy underlying an optogenetic neural interface comprising stretchable and transparent conductive tracks and capable of demonstrating high biocompatibility after long-term (5-month) implantation. Ag/Au core–shell nanowires contribute toward improving track performance in terms of stretchability (<60% strain), transparency (<83%), and electrical resistance (15 Ω sq−1). The neural interface integrated with gel-coated exterior microelectrodes preserves low impedance (1.1–3.2 Ω cm2) in a saline solution over the evaluated 5-month period. Besides the use of efficient conductive materials, surface treatment using antithrombogenic polymer tends to prevent the growth of granulation tissue, thereby facilitating clear monitoring of electrocorticograms (ECoG) in a rodent during chronic implantation. The flexible and transparent neural interface pathologically exhibits noncytotoxicity and low inflammatory response while efficiently recording evoked ECoG in a nonhuman primate via optogenetic stimulation. The proposed highly reliable interface can be employed in multifaceted approaches for translational research based on chronic implants.

Original languageEnglish
Article number1900130
JournalAdvanced Healthcare Materials
Volume8
Issue number10
DOIs
Publication statusPublished - May 23 2019

Fingerprint

Optogenetics
Nanowires
Conductive materials
Acoustic impedance
Granulation
Microelectrodes
Biocompatibility
Sodium Chloride
Transparency
Surface treatment
Polymers
Gels
Tissue
Electric Impedance
Monitoring
Translational Medical Research
Granulation Tissue
Primates
Rodentia
Light

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Araki, T., Yoshida, F., Uemura, T., Noda, Y., Yoshimoto, S., Kaiju, T., ... Sekitani, T. (2019). Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core–Shell Nanowires. Advanced Healthcare Materials, 8(10), [1900130]. https://doi.org/10.1002/adhm.201900130

Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core–Shell Nanowires. / Araki, Teppei; Yoshida, Fumiaki; Uemura, Takafumi; Noda, Yuki; Yoshimoto, Shusuke; Kaiju, Taro; Suzuki, Takafumi; Hamanaka, Hiroki; Baba, Kousuke; Hayakawa, Hideki; Yabumoto, Taiki; Mochizuki, Hideki; Kobayashi, Shingo; Tanaka, Masaru; Hirata, Masayuki; Sekitani, Tsuyoshi.

In: Advanced Healthcare Materials, Vol. 8, No. 10, 1900130, 23.05.2019.

Research output: Contribution to journalArticle

Araki, T, Yoshida, F, Uemura, T, Noda, Y, Yoshimoto, S, Kaiju, T, Suzuki, T, Hamanaka, H, Baba, K, Hayakawa, H, Yabumoto, T, Mochizuki, H, Kobayashi, S, Tanaka, M, Hirata, M & Sekitani, T 2019, 'Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core–Shell Nanowires', Advanced Healthcare Materials, vol. 8, no. 10, 1900130. https://doi.org/10.1002/adhm.201900130
Araki, Teppei ; Yoshida, Fumiaki ; Uemura, Takafumi ; Noda, Yuki ; Yoshimoto, Shusuke ; Kaiju, Taro ; Suzuki, Takafumi ; Hamanaka, Hiroki ; Baba, Kousuke ; Hayakawa, Hideki ; Yabumoto, Taiki ; Mochizuki, Hideki ; Kobayashi, Shingo ; Tanaka, Masaru ; Hirata, Masayuki ; Sekitani, Tsuyoshi. / Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core–Shell Nanowires. In: Advanced Healthcare Materials. 2019 ; Vol. 8, No. 10.
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