Long-term outcome of adipose-derived regenerative cell-enriched autologous fat transplantation for reconstruction after breast-conserving surgery for Japanese women with breast cancer

Shuhei Ito, Yuichiro Kai, Takaaki Masuda, Fumiaki Tanaka, Toshifumi Matsumoto, Yukio Kamohara, Hiroshi Hayakawa, Hiroaki Ueo, Hideki Iwaguro, Marc H. Hedrick, Koshi Mimori, Masaki Mori

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: More effective methods are needed for breast reconstruction after breast-conserving surgery for breast cancer. The aim of this clinical study was to assess the perioperative and long-term outcomes of adipose-derived regenerative cell (ADRC)-enriched autologous fat grafting. Methods: Ten female patients who had undergone breast-conserving surgery and adjuvant radiotherapy for breast cancer were enrolled. An ADRC-enriched fat graft prepared from the patient’s adipose tissue was implanted at the time of adipose tissue harvest. The perioperative and long-term outcomes of the grafts, which included safety, efficacy, and questionnaire-based patient satisfaction, were investigated. Results: The mean operation time was 188 ± 30 min, and the mean duration of postoperative hospitalization was 1.2 ± 0.4 days. No serious postoperative complications were associated with the procedure. Neither recurrence nor metastatic disease was observed during the follow-up period (7.8 ± 1.5 years) after transplantation. Of 9 available patients, “more than or equal to average” satisfaction with breast appearance and overall satisfaction were reported by 6 (66.7%) and 5 (55.6%) patients, respectively. Conclusions: ADRC-enriched autologous fat transplantation is thus considered to be safe perioperatively, with no long-term recurrence, for patients with breast cancer treated by breast-conserving surgery, and it may be an option for breast reconstruction, even after adjuvant radiotherapy.

Original languageEnglish
Pages (from-to)1500-1511
Number of pages12
JournalSurgery today
Volume47
Issue number12
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Segmental Mastectomy
Autologous Transplantation
Fats
Breast Neoplasms
Adjuvant Radiotherapy
Mammaplasty
Adipose Tissue
Transplants
Recurrence
Patient Satisfaction
Adipocytes
Hospitalization
Breast
Transplantation
Safety

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Long-term outcome of adipose-derived regenerative cell-enriched autologous fat transplantation for reconstruction after breast-conserving surgery for Japanese women with breast cancer. / Ito, Shuhei; Kai, Yuichiro; Masuda, Takaaki; Tanaka, Fumiaki; Matsumoto, Toshifumi; Kamohara, Yukio; Hayakawa, Hiroshi; Ueo, Hiroaki; Iwaguro, Hideki; Hedrick, Marc H.; Mimori, Koshi; Mori, Masaki.

In: Surgery today, Vol. 47, No. 12, 01.12.2017, p. 1500-1511.

Research output: Contribution to journalArticle

Ito, Shuhei ; Kai, Yuichiro ; Masuda, Takaaki ; Tanaka, Fumiaki ; Matsumoto, Toshifumi ; Kamohara, Yukio ; Hayakawa, Hiroshi ; Ueo, Hiroaki ; Iwaguro, Hideki ; Hedrick, Marc H. ; Mimori, Koshi ; Mori, Masaki. / Long-term outcome of adipose-derived regenerative cell-enriched autologous fat transplantation for reconstruction after breast-conserving surgery for Japanese women with breast cancer. In: Surgery today. 2017 ; Vol. 47, No. 12. pp. 1500-1511.
@article{7854b384a10d42439ec02f606e2ed0b3,
title = "Long-term outcome of adipose-derived regenerative cell-enriched autologous fat transplantation for reconstruction after breast-conserving surgery for Japanese women with breast cancer",
abstract = "Purpose: More effective methods are needed for breast reconstruction after breast-conserving surgery for breast cancer. The aim of this clinical study was to assess the perioperative and long-term outcomes of adipose-derived regenerative cell (ADRC)-enriched autologous fat grafting. Methods: Ten female patients who had undergone breast-conserving surgery and adjuvant radiotherapy for breast cancer were enrolled. An ADRC-enriched fat graft prepared from the patient’s adipose tissue was implanted at the time of adipose tissue harvest. The perioperative and long-term outcomes of the grafts, which included safety, efficacy, and questionnaire-based patient satisfaction, were investigated. Results: The mean operation time was 188 ± 30 min, and the mean duration of postoperative hospitalization was 1.2 ± 0.4 days. No serious postoperative complications were associated with the procedure. Neither recurrence nor metastatic disease was observed during the follow-up period (7.8 ± 1.5 years) after transplantation. Of 9 available patients, “more than or equal to average” satisfaction with breast appearance and overall satisfaction were reported by 6 (66.7{\%}) and 5 (55.6{\%}) patients, respectively. Conclusions: ADRC-enriched autologous fat transplantation is thus considered to be safe perioperatively, with no long-term recurrence, for patients with breast cancer treated by breast-conserving surgery, and it may be an option for breast reconstruction, even after adjuvant radiotherapy.",
author = "Shuhei Ito and Yuichiro Kai and Takaaki Masuda and Fumiaki Tanaka and Toshifumi Matsumoto and Yukio Kamohara and Hiroshi Hayakawa and Hiroaki Ueo and Hideki Iwaguro and Hedrick, {Marc H.} and Koshi Mimori and Masaki Mori",
year = "2017",
month = "12",
day = "1",
doi = "10.1007/s00595-017-1544-4",
language = "English",
volume = "47",
pages = "1500--1511",
journal = "Surgery Today",
issn = "0941-1291",
publisher = "Springer Japan",
number = "12",

}

TY - JOUR

T1 - Long-term outcome of adipose-derived regenerative cell-enriched autologous fat transplantation for reconstruction after breast-conserving surgery for Japanese women with breast cancer

AU - Ito, Shuhei

AU - Kai, Yuichiro

AU - Masuda, Takaaki

AU - Tanaka, Fumiaki

AU - Matsumoto, Toshifumi

AU - Kamohara, Yukio

AU - Hayakawa, Hiroshi

AU - Ueo, Hiroaki

AU - Iwaguro, Hideki

AU - Hedrick, Marc H.

AU - Mimori, Koshi

AU - Mori, Masaki

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Purpose: More effective methods are needed for breast reconstruction after breast-conserving surgery for breast cancer. The aim of this clinical study was to assess the perioperative and long-term outcomes of adipose-derived regenerative cell (ADRC)-enriched autologous fat grafting. Methods: Ten female patients who had undergone breast-conserving surgery and adjuvant radiotherapy for breast cancer were enrolled. An ADRC-enriched fat graft prepared from the patient’s adipose tissue was implanted at the time of adipose tissue harvest. The perioperative and long-term outcomes of the grafts, which included safety, efficacy, and questionnaire-based patient satisfaction, were investigated. Results: The mean operation time was 188 ± 30 min, and the mean duration of postoperative hospitalization was 1.2 ± 0.4 days. No serious postoperative complications were associated with the procedure. Neither recurrence nor metastatic disease was observed during the follow-up period (7.8 ± 1.5 years) after transplantation. Of 9 available patients, “more than or equal to average” satisfaction with breast appearance and overall satisfaction were reported by 6 (66.7%) and 5 (55.6%) patients, respectively. Conclusions: ADRC-enriched autologous fat transplantation is thus considered to be safe perioperatively, with no long-term recurrence, for patients with breast cancer treated by breast-conserving surgery, and it may be an option for breast reconstruction, even after adjuvant radiotherapy.

AB - Purpose: More effective methods are needed for breast reconstruction after breast-conserving surgery for breast cancer. The aim of this clinical study was to assess the perioperative and long-term outcomes of adipose-derived regenerative cell (ADRC)-enriched autologous fat grafting. Methods: Ten female patients who had undergone breast-conserving surgery and adjuvant radiotherapy for breast cancer were enrolled. An ADRC-enriched fat graft prepared from the patient’s adipose tissue was implanted at the time of adipose tissue harvest. The perioperative and long-term outcomes of the grafts, which included safety, efficacy, and questionnaire-based patient satisfaction, were investigated. Results: The mean operation time was 188 ± 30 min, and the mean duration of postoperative hospitalization was 1.2 ± 0.4 days. No serious postoperative complications were associated with the procedure. Neither recurrence nor metastatic disease was observed during the follow-up period (7.8 ± 1.5 years) after transplantation. Of 9 available patients, “more than or equal to average” satisfaction with breast appearance and overall satisfaction were reported by 6 (66.7%) and 5 (55.6%) patients, respectively. Conclusions: ADRC-enriched autologous fat transplantation is thus considered to be safe perioperatively, with no long-term recurrence, for patients with breast cancer treated by breast-conserving surgery, and it may be an option for breast reconstruction, even after adjuvant radiotherapy.

UR - http://www.scopus.com/inward/record.url?scp=85019751303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019751303&partnerID=8YFLogxK

U2 - 10.1007/s00595-017-1544-4

DO - 10.1007/s00595-017-1544-4

M3 - Article

C2 - 28555267

AN - SCOPUS:85019751303

VL - 47

SP - 1500

EP - 1511

JO - Surgery Today

JF - Surgery Today

SN - 0941-1291

IS - 12

ER -