Long-term outcome of cord blood transplantation from unrelated donors as an initial transplantation procedure for children with AML in Japan

K. Isoyama, M. Oda, K. Kato, T. Nagamura-Inoue, S. Kai, H. Kigasawa, R. Kobayashi, J. Mimaya, M. Inoue, A. Kikuchi, S. Kato

Research output: Contribution to journalArticle

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Abstract

To assess the outcome of unrelated umbilical cord blood transplantation (UCBT), 141 children with AML who underwent UCBT (39 in first CR (CR1), 33 in CR2, 4 in CR3 and 65 at more advanced stages (not in CR)) were analyzed in a retrospective multicenter study in Japan. Short-term MTX was used for prophylaxis of acute GVHD in 80 cases (57%). The cumulative incidences of neutrophil recovery, platelet recovery and acute GVHD (grades 2-4) were 78.7, 62.4 and 40.1%, respectively, and the 100-day transplantation-related mortality (TRM) was 10.8%. Multivariate analysis showed that an infused CD34+ cell dose of 1.35 × 105 cells per kg or more was associated with favorable neutrophil and platelet recovery, and that short-term MTX was associated with a lower 100-day TRM. The 6-year relapse rate was 38.8% and was associated with disease status. Six-year overall survival was 45.8% (70.4 ± 8.3% in CR1, 59.3 ± 11.3% in CR2, 75.5 ± 21% in CR3 and 20.6 ± 6.2% for children with non-CR). We conclude that the results of UCBT are particularly promising for children with a karyotype suggesting a poor prognosis, and for those who receive transplants in CR2 and CR3 after an early relapse.

Original languageEnglish
Pages (from-to)69-77
Number of pages9
JournalBone Marrow Transplantation
Volume45
Issue number1
DOIs
Publication statusPublished - Jan 1 2010
Externally publishedYes

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Unrelated Donors
Fetal Blood
Japan
Transplantation
Neutrophils
Blood Platelets
Recurrence
Mortality
Karyotype
Multicenter Studies
Multivariate Analysis
Retrospective Studies
Transplants
Incidence

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Long-term outcome of cord blood transplantation from unrelated donors as an initial transplantation procedure for children with AML in Japan. / Isoyama, K.; Oda, M.; Kato, K.; Nagamura-Inoue, T.; Kai, S.; Kigasawa, H.; Kobayashi, R.; Mimaya, J.; Inoue, M.; Kikuchi, A.; Kato, S.

In: Bone Marrow Transplantation, Vol. 45, No. 1, 01.01.2010, p. 69-77.

Research output: Contribution to journalArticle

Isoyama, K, Oda, M, Kato, K, Nagamura-Inoue, T, Kai, S, Kigasawa, H, Kobayashi, R, Mimaya, J, Inoue, M, Kikuchi, A & Kato, S 2010, 'Long-term outcome of cord blood transplantation from unrelated donors as an initial transplantation procedure for children with AML in Japan', Bone Marrow Transplantation, vol. 45, no. 1, pp. 69-77. https://doi.org/10.1038/bmt.2009.93
Isoyama, K. ; Oda, M. ; Kato, K. ; Nagamura-Inoue, T. ; Kai, S. ; Kigasawa, H. ; Kobayashi, R. ; Mimaya, J. ; Inoue, M. ; Kikuchi, A. ; Kato, S. / Long-term outcome of cord blood transplantation from unrelated donors as an initial transplantation procedure for children with AML in Japan. In: Bone Marrow Transplantation. 2010 ; Vol. 45, No. 1. pp. 69-77.
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