Long-term outcome of living-donor liver transplantation for combined hepatocellular-cholangiocarcinoma

Shinji Itoh, Toru Ikegami, Tomoharu Yoshizumi, Huanlin Wang, Kazuki Takeishi, Norifumi Harimoto, Yo Ichi Yamashita, Hirofumi Kawanaka, Shinichi Aishima, Ken Shirabe, Yoshihiko Maehara

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Abstract

Background/Aim: Combined hepatocellular-cholangio carcinoma (cHC-CC) is found unexpectedly in explanted or resected liver specimens. The current study evaluated the longterm outcomes of living-donor liver transplantation (LDLT) between patients with cHC-CC and hepatocellular carcinoma (HCC). Patients and Methods: We performed 178 LDLT including 8 patients of pathologically and immunohistochemically diagnosed cHC-CC who all under went LDLT with a preoperative diagnosis of HCC by ima ging study. Results: Out of the 8 patients, 6 were within the Milan criteria and all were within the Kyushu University criteria. The 1-, 5- and 10-year overall survival (OS) and disease-free survival (DFS) rates after LDLT for patients with cHC-CC were 87.5, 72.9 and 48.6% and 85.7, 85.7 and 85.7%, respectively. The OS and DFS between patients with cHC-CC and HCC were not statistically different. Conclusion: LDLT for patients with cHC-CC using the Milan criteria or the Kyushu University criteria, as well as HCC, could have an acceptable long-term outcome.

Original languageEnglish
Pages (from-to)2475-2476
Number of pages2
JournalAnticancer research
Volume35
Issue number4
Publication statusPublished - Apr 1 2015

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Cholangiocarcinoma
Living Donors
Liver Transplantation
Hepatocellular Carcinoma
Disease-Free Survival
Survival
Survival Rate

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Long-term outcome of living-donor liver transplantation for combined hepatocellular-cholangiocarcinoma. / Itoh, Shinji; Ikegami, Toru; Yoshizumi, Tomoharu; Wang, Huanlin; Takeishi, Kazuki; Harimoto, Norifumi; Yamashita, Yo Ichi; Kawanaka, Hirofumi; Aishima, Shinichi; Shirabe, Ken; Maehara, Yoshihiko.

In: Anticancer research, Vol. 35, No. 4, 01.04.2015, p. 2475-2476.

Research output: Contribution to journalArticle

Itoh, S, Ikegami, T, Yoshizumi, T, Wang, H, Takeishi, K, Harimoto, N, Yamashita, YI, Kawanaka, H, Aishima, S, Shirabe, K & Maehara, Y 2015, 'Long-term outcome of living-donor liver transplantation for combined hepatocellular-cholangiocarcinoma', Anticancer research, vol. 35, no. 4, pp. 2475-2476.
Itoh, Shinji ; Ikegami, Toru ; Yoshizumi, Tomoharu ; Wang, Huanlin ; Takeishi, Kazuki ; Harimoto, Norifumi ; Yamashita, Yo Ichi ; Kawanaka, Hirofumi ; Aishima, Shinichi ; Shirabe, Ken ; Maehara, Yoshihiko. / Long-term outcome of living-donor liver transplantation for combined hepatocellular-cholangiocarcinoma. In: Anticancer research. 2015 ; Vol. 35, No. 4. pp. 2475-2476.
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