Long-term results of proton beam therapy for carcinoma of the uterine cervix

Kenji Kagei, Koichi Tokuuye, Toshiyuki Okumura, Kiyoshi Ohara, Yoshiyuki Shioyama, Shinji Sugahara, Yasuyuki Akine

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39 Citations (Scopus)

Abstract

Purpose: To determine the role of proton therapy in patients with carcinoma of the uterine cervix. Methods and Materials: Between 1983 and 1991, 25 patients with squamous cell carcinoma of the uterine cervix (stages IIB-IVA) were treated with a curative intent by external photon irradiation to the pelvis, followed by proton irradiation to the primary tumor, delivering a median total tumor dose of 86 Gy (range 71 Gy/26 Fr-101 Gy/46 Fr), and were followed for a median period of 139 months (range 11-184 months). Results: Ten-year overall survival rates for stages IIB and IIIB/IVA patients were 89% and 40%, respectively. Five-year local control rates for stages IIB and IIIB/IVA patients were 100% and 61%, respectively. Four percent of patients experienced severe (Grade 4 or more) late complications in the intestine or urinary bladder at 5 years. Conclusions: External photon and proton therapy is effective for those who are not eligible for intracavitary irradiation, and who otherwise have a poor prognosis. The results show that tumor control, survival, and morbidity are similar to those after conventional therapy.

Original languageEnglish
Pages (from-to)1265-1271
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume55
Issue number5
DOIs
Publication statusPublished - Apr 1 2003

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All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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