Long-term smoking causes more advanced coronary endothelial dysfunction in middle-aged smokers compared to young smokers

Masanao Naya, Koichi Morita, Keiichiro Yoshinaga, Osamu Manabe, Daisuke Goto, Kenji Hirata, Chietsugu Katoh, Nagara Tamaki, Hiroyuki Tsutsui

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose Smoking cessation has been shown to normalize the coronary endothelial dysfunction in healthy young smokers. However, its effect has not been explored in middle-aged smokers with a longer history of smoking. Therefore, we compared the effects of smoking cessation on coronary vasomotor response between both young and middle-aged smokers and identified the predictor for its improvement. Methods This study investigated 14 young healthy smokers (age 25.2±2.3 years), 13 middle-aged smokers (age 42.0± 6.5 years) and 10 non-smokers. Myocardial blood flow (MBF) was measured by using 15O-water positron emission tomography (PET). Results At baseline, the ratio of MBF during the cold pressor test (CPT) to that at rest (MBF CPT /rest), the index of coronary endothelial function, was significantly decreased in both young and middle-aged smokers compared to nonsmokers (1.24±0.20 and 1.10±0.39 vs 1.53±0.18, p<0.05 and p<0.001, respectively). The ratio of MBF during adenosine triphosphate infusion to that at rest was significantly decreased in middle-aged smokers compared to young smokers and non-smokers (3.34±1.52 vs 4.43±0.92 and 4.69±1.25, p<0.05, respectively). MBF CPT /rest at 1 month after smoking cessation significantly increased in young smokers, but not in middle-aged smokers. By multivariate analysis, baseline serum malondialdehydemodified low-density lipoprotein (MDA-LDL) was an independent predictor for the changes in MBF CPT /rest after smoking cessation (β=-0.45, p<0.05). Conclusion Coronary endothelial dysfunction was reversible by short-term smoking cessation in young smokers, but not in middle-aged smokers, which was associated with serum MDA-LDL levels. Long-term smoking exposure could lead to more advanced coronary endothelial dysfunction and atherosclerosis possibly via oxidative stress.

Original languageEnglish
Pages (from-to)491-498
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume38
Issue number3
DOIs
Publication statusPublished - Mar 1 2011
Externally publishedYes

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Smoking Cessation
Smoking
LDL Lipoproteins
Serum
Positron-Emission Tomography
Atherosclerosis
Oxidative Stress
Multivariate Analysis
Adenosine Triphosphate
Water

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Long-term smoking causes more advanced coronary endothelial dysfunction in middle-aged smokers compared to young smokers. / Naya, Masanao; Morita, Koichi; Yoshinaga, Keiichiro; Manabe, Osamu; Goto, Daisuke; Hirata, Kenji; Katoh, Chietsugu; Tamaki, Nagara; Tsutsui, Hiroyuki.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 38, No. 3, 01.03.2011, p. 491-498.

Research output: Contribution to journalArticle

Naya, Masanao ; Morita, Koichi ; Yoshinaga, Keiichiro ; Manabe, Osamu ; Goto, Daisuke ; Hirata, Kenji ; Katoh, Chietsugu ; Tamaki, Nagara ; Tsutsui, Hiroyuki. / Long-term smoking causes more advanced coronary endothelial dysfunction in middle-aged smokers compared to young smokers. In: European Journal of Nuclear Medicine and Molecular Imaging. 2011 ; Vol. 38, No. 3. pp. 491-498.
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AU - Naya, Masanao

AU - Morita, Koichi

AU - Yoshinaga, Keiichiro

AU - Manabe, Osamu

AU - Goto, Daisuke

AU - Hirata, Kenji

AU - Katoh, Chietsugu

AU - Tamaki, Nagara

AU - Tsutsui, Hiroyuki

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N2 - Purpose Smoking cessation has been shown to normalize the coronary endothelial dysfunction in healthy young smokers. However, its effect has not been explored in middle-aged smokers with a longer history of smoking. Therefore, we compared the effects of smoking cessation on coronary vasomotor response between both young and middle-aged smokers and identified the predictor for its improvement. Methods This study investigated 14 young healthy smokers (age 25.2±2.3 years), 13 middle-aged smokers (age 42.0± 6.5 years) and 10 non-smokers. Myocardial blood flow (MBF) was measured by using 15O-water positron emission tomography (PET). Results At baseline, the ratio of MBF during the cold pressor test (CPT) to that at rest (MBF CPT /rest), the index of coronary endothelial function, was significantly decreased in both young and middle-aged smokers compared to nonsmokers (1.24±0.20 and 1.10±0.39 vs 1.53±0.18, p<0.05 and p<0.001, respectively). The ratio of MBF during adenosine triphosphate infusion to that at rest was significantly decreased in middle-aged smokers compared to young smokers and non-smokers (3.34±1.52 vs 4.43±0.92 and 4.69±1.25, p<0.05, respectively). MBF CPT /rest at 1 month after smoking cessation significantly increased in young smokers, but not in middle-aged smokers. By multivariate analysis, baseline serum malondialdehydemodified low-density lipoprotein (MDA-LDL) was an independent predictor for the changes in MBF CPT /rest after smoking cessation (β=-0.45, p<0.05). Conclusion Coronary endothelial dysfunction was reversible by short-term smoking cessation in young smokers, but not in middle-aged smokers, which was associated with serum MDA-LDL levels. Long-term smoking exposure could lead to more advanced coronary endothelial dysfunction and atherosclerosis possibly via oxidative stress.

AB - Purpose Smoking cessation has been shown to normalize the coronary endothelial dysfunction in healthy young smokers. However, its effect has not been explored in middle-aged smokers with a longer history of smoking. Therefore, we compared the effects of smoking cessation on coronary vasomotor response between both young and middle-aged smokers and identified the predictor for its improvement. Methods This study investigated 14 young healthy smokers (age 25.2±2.3 years), 13 middle-aged smokers (age 42.0± 6.5 years) and 10 non-smokers. Myocardial blood flow (MBF) was measured by using 15O-water positron emission tomography (PET). Results At baseline, the ratio of MBF during the cold pressor test (CPT) to that at rest (MBF CPT /rest), the index of coronary endothelial function, was significantly decreased in both young and middle-aged smokers compared to nonsmokers (1.24±0.20 and 1.10±0.39 vs 1.53±0.18, p<0.05 and p<0.001, respectively). The ratio of MBF during adenosine triphosphate infusion to that at rest was significantly decreased in middle-aged smokers compared to young smokers and non-smokers (3.34±1.52 vs 4.43±0.92 and 4.69±1.25, p<0.05, respectively). MBF CPT /rest at 1 month after smoking cessation significantly increased in young smokers, but not in middle-aged smokers. By multivariate analysis, baseline serum malondialdehydemodified low-density lipoprotein (MDA-LDL) was an independent predictor for the changes in MBF CPT /rest after smoking cessation (β=-0.45, p<0.05). Conclusion Coronary endothelial dysfunction was reversible by short-term smoking cessation in young smokers, but not in middle-aged smokers, which was associated with serum MDA-LDL levels. Long-term smoking exposure could lead to more advanced coronary endothelial dysfunction and atherosclerosis possibly via oxidative stress.

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