Long-term treatment with panitumumab monotherapy for recurrent colorectal cancer

Koji Ando, Eiji Oki, Hiroshi Saeki, Yuichiro Nakashima, Yoshihiko Maehara

Research output: Contribution to journalArticlepeer-review

Abstract

With the development of new chemotherapy agents and methods, metastatic colorectal cancer patients can now achieve a survival time of >30 months. Higher line therapies have had a significant influence on the survival of these patients. However, it remains uncertain as to which therapy is the most effective and best tolerated. Herein, we describe the case of a patient with metastatic KRAS wild-type colorectal cancer who received panitumumab monotherapy as a third-line therapy after failure of 5-fluorouracil, irinotecan, oxaliplatin and bevacizumab. This patient had both lymph node and lung recurrence. The patient achieved a partial response time of 15 months. The lymph node and recurrent lung tumor had shrunk by 74 and 100 %, respectively, and the treatment was well tolerated with limited cutaneous toxicity. Panitumumab monotherapy may be an effective and well-tolerated treatment of KRAS wild-type metastatic colorectal cancer patients who have undergone many prior therapies. The present case showed a response to panitumumab monotherapy extending over a period of >1 year.
Original languageEnglish
Pages (from-to)151
Number of pages154
JournalInternational Cancer Conference Journal
Volume4
Issue number3
Publication statusPublished - Jul 2015

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