Longitudinal changes in symptoms and plasma homovanillic acid levels in chronically medicated schizophrenic patients

Eiji Suzuki, Shigenobu Kanba, Masashi Nibuya, Sunao Adachi, Utako Sekiya, Futoshi Shintani, Norihasa Kinoshita, Gohei Yagi, Masahiro Asai

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A correlation has been noted between the changes in plasma homovanillic acid concentrations and changes in psychiatricy symptoms induced by neuroleptic treatment. Our objective was to determine whether plasma homovanillic acid concentration changed in accordance with the changes in symptoms over time. Twenty-eight chronically medicated schizophrenic inpatients received the same treatment regimen for 1 year. Symptoms and plasma homovanillic acid concentrations were examined every month and whenever conditions deteriorated. Plasma homovanillic acid concentrations were significantly higher in the patients in the worst condition than in the patients in the best condition. Further, when comparing the best and worst conditions of both the positive and negative symptoms, the change in psychiatric rating of positive and negative symptoms was correlated significantly with the change in plasma homovanillic acid level. These results suggest that a change in plasma homovanillic acid concentration can be produced not only by neuroleptic-induced dopaminergic blocking but also by a change in positive and negative symptoms of schizophrenia.

Original languageEnglish
Pages (from-to)654-661
Number of pages8
JournalBiological Psychiatry
Volume36
Issue number10
DOIs
Publication statusPublished - Nov 15 1994
Externally publishedYes

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Homovanillic Acid
Antipsychotic Agents
Psychiatry
Inpatients
Schizophrenia
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry

Cite this

Longitudinal changes in symptoms and plasma homovanillic acid levels in chronically medicated schizophrenic patients. / Suzuki, Eiji; Kanba, Shigenobu; Nibuya, Masashi; Adachi, Sunao; Sekiya, Utako; Shintani, Futoshi; Kinoshita, Norihasa; Yagi, Gohei; Asai, Masahiro.

In: Biological Psychiatry, Vol. 36, No. 10, 15.11.1994, p. 654-661.

Research output: Contribution to journalArticle

Suzuki, E, Kanba, S, Nibuya, M, Adachi, S, Sekiya, U, Shintani, F, Kinoshita, N, Yagi, G & Asai, M 1994, 'Longitudinal changes in symptoms and plasma homovanillic acid levels in chronically medicated schizophrenic patients', Biological Psychiatry, vol. 36, no. 10, pp. 654-661. https://doi.org/10.1016/0006-3223(94)91174-6
Suzuki, Eiji ; Kanba, Shigenobu ; Nibuya, Masashi ; Adachi, Sunao ; Sekiya, Utako ; Shintani, Futoshi ; Kinoshita, Norihasa ; Yagi, Gohei ; Asai, Masahiro. / Longitudinal changes in symptoms and plasma homovanillic acid levels in chronically medicated schizophrenic patients. In: Biological Psychiatry. 1994 ; Vol. 36, No. 10. pp. 654-661.
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