TY - JOUR
T1 - Loss of 6q or 8p23 is associated with the total number of DNA copy number aberrations in adenoid cystic carcinoma
AU - Oga, Atsunori
AU - Uchida, Kenichiro
AU - Nakao, Motonao
AU - Kawauchi, Shigeto
AU - Furuya, Tomoko
AU - Chochi, Yasuyo
AU - Ikemoto, Kenzo
AU - Okada, Takae
AU - Ueyama, Yoshiya
AU - Sasaki, Kohsuke
AU - Yousefpour, Fatemeh
PY - 2011/12
Y1 - 2011/12
N2 - We analyzed 10 adenoid cystic carcinomas (ACCs) of the salivary glands by array-based comparative genomic hybridization (a-CGH) using DNA chips spotted with 4,030 bacterial artificial chromosome clones. After the data smoothing procedure was applied, a total of 88 DNA copy number aberrations (DCNAs) were detected. The frequent (≥30%) DCNAs were loss of 6q23-27 and 8p23, and gains of 6p, 6q23, 8p23 and 22q13. High-level gains were detected on 12q15, including MDM2 in two cases. These two cases showed an immunohistochemically high-level (>50%) expression of MDM2 and a low-level expression of p53 (<20%). Furthermore, the total number of DCNAs was significantly greater in ACCs with loss of 6q compared to other ACCs, and in ACCs without the loss of 8p23 compared to other ACCs, respectively. Although limitations exist, a-CGH detected several candidate chromosomal imbalances associated with accumulation of DCNAs in ACCs.
AB - We analyzed 10 adenoid cystic carcinomas (ACCs) of the salivary glands by array-based comparative genomic hybridization (a-CGH) using DNA chips spotted with 4,030 bacterial artificial chromosome clones. After the data smoothing procedure was applied, a total of 88 DNA copy number aberrations (DCNAs) were detected. The frequent (≥30%) DCNAs were loss of 6q23-27 and 8p23, and gains of 6p, 6q23, 8p23 and 22q13. High-level gains were detected on 12q15, including MDM2 in two cases. These two cases showed an immunohistochemically high-level (>50%) expression of MDM2 and a low-level expression of p53 (<20%). Furthermore, the total number of DCNAs was significantly greater in ACCs with loss of 6q compared to other ACCs, and in ACCs without the loss of 8p23 compared to other ACCs, respectively. Although limitations exist, a-CGH detected several candidate chromosomal imbalances associated with accumulation of DCNAs in ACCs.
UR - http://www.scopus.com/inward/record.url?scp=80053471996&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053471996&partnerID=8YFLogxK
U2 - 10.3892/or.2011.1446
DO - 10.3892/or.2011.1446
M3 - Article
C2 - 21894435
AN - SCOPUS:80053471996
SN - 1021-335X
VL - 26
SP - 1393
EP - 1398
JO - Oncology Reports
JF - Oncology Reports
IS - 6
ER -
