Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system

Lixiang Wang, Masatoshi Nomura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Dynamin-related protein 1 (Drp1) is a member of the dynamin family of large GTPase, which cycles between the cytosol and the mitochondrial outer membrane, and mediates mitochondrial fission. Using microarray analysis of gene expression in the livers of wild-type and Drp1 knockout mice, we have previously identified that endoplasmic reticulum (ER) stress marker genes are significantly increased by the absence of Drp1 [1]. Here, we provide methodological and analytical details of the microarray data, which have been deposited in the Gene Expression Omnibus as data set GSE64222. We have performed further gene ontology analysis of the data and found the differential expression of a subset of genes that are involved in the immune response in the livers of Drp1 knockout mice versus wild-type controls.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalGenomics Data
Volume6
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Dynamins
Immune system
Liver
Immune System
Genes
Gene Expression
Microarrays
Proteins
Gene expression
Knockout Mice
Mitochondrial Dynamics
Gene Ontology
Endoplasmic Reticulum Stress
GTP Phosphohydrolases
Mitochondrial Membranes
Microarray Analysis
Cytosol
Ontology
Membranes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Genetics

Cite this

Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system. / Wang, Lixiang; Nomura, Masatoshi.

In: Genomics Data, Vol. 6, 01.12.2015, p. 27-30.

Research output: Contribution to journalArticle

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