TY - JOUR
T1 - Loss of heterozygosity analysis in malignant gliomas
AU - Mizoguchi, Masahiro
AU - Kuga, Daisuke
AU - Guan, Yanlei
AU - Hata, Nobuhiro
AU - Nakamizo, Akira
AU - Yoshimoto, Koji
AU - Sasaki, Tomio
N1 - Funding Information:
Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan; grant no. 2390280 (M. Mizoguchi).
PY - 2011/7
Y1 - 2011/7
N2 - Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy. Some of the identified molecular markers-such as loss of heterozygosity (LOH) on chromosome 1p/19q and chromosome 10, O6-methylguanine methyltransferase promoter hypermethylation, and mutation of isocitrate dehydrogenase-1-may help to predict patient outcomes. Indeed, LOH analysis is an effective approach to classify malignant gliomas. Genome-wide analyses have revealed that the extent and pattern of LOH regions may have important implications for the clinical course of the disease. As the genetic underpinnings of malignant gliomas are complex and varied, careful selection of the methods for genetic analysis in the clinic is important. The fundamental principles of each assay need to be understood to allow careful selection of practically useful methods. This review summarizes recent developments in the molecular analysis of malignant glioma.
AB - Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy. Some of the identified molecular markers-such as loss of heterozygosity (LOH) on chromosome 1p/19q and chromosome 10, O6-methylguanine methyltransferase promoter hypermethylation, and mutation of isocitrate dehydrogenase-1-may help to predict patient outcomes. Indeed, LOH analysis is an effective approach to classify malignant gliomas. Genome-wide analyses have revealed that the extent and pattern of LOH regions may have important implications for the clinical course of the disease. As the genetic underpinnings of malignant gliomas are complex and varied, careful selection of the methods for genetic analysis in the clinic is important. The fundamental principles of each assay need to be understood to allow careful selection of practically useful methods. This review summarizes recent developments in the molecular analysis of malignant glioma.
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U2 - 10.1007/s10014-011-0038-0
DO - 10.1007/s10014-011-0038-0
M3 - Article
C2 - 21629980
AN - SCOPUS:80052751470
VL - 28
SP - 191
EP - 196
JO - Brain Tumor Pathology
JF - Brain Tumor Pathology
SN - 1433-7398
IS - 3
ER -