We recently isolated from differential displays and subsequently cloned a human α-intercrine (hIRH) whose mRNA is reduced in human hepatocellular carcinomas. We now report that on Northern blots its mRNA is absent from premalignant colonic adenomas and from all of 27 human malignant cell lines (including breast, cervix, colon, duodenal, gastric, leukemia, liver, lung, melanoma, and pancreatic lines). hIRH mRNA was present in most normal human and mouse tissues and fibroblast derived cell lines but absent from leukocytes and brain. Two mRNA signals, at ~ 2 Kb and ~ 3.5 Kb, had variation in signal strength or size between tissues and species.
|Number of pages||5|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - Dec 24 1996|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology