Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization

Nobuaki Egashira, Yoshiaki Matsumoto, Kenichi Mishima, Katsunori Iwasaki, Masayuki Fujioka, Michihiko Matsushita, Yukihiro Shoyama, Ryoji Nishimura, Michihiro Fujiwara

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33 Citations (Scopus)

Abstract

Citalopram, a selective serotonin reuptake inhibitor (SSRI), is one of the most widely used antidepressants. Recently, citalopram has been reported to improve working memory in patients with depression, and psychotic symptoms and behavioral disturbances in patients with dementia. However, the possibility of using citalopram in the treatment of cognitive disorders has not received much attention. The present study investigated the effects of citalopram on scopolamine- and Δ9-tetrahydrocannabinol (THC)-induced impairment of spatial memory using an eight-arm radial maze and electroconvulsive shock (ECS)-induced immobilization (a behavioral model for the disturbance of consciousness). Low dose citalopram reversed both scopolamine- and THC-induced impairment of spatial memory, suppressed ECS-induced immobilization reversed the THC-induced decrease of acetylcholine (ACh) release in the dorsal hippocampus in vivo microdialysis, and enhanced tremors induced by oxotremorine, a muscarinic M1 receptor agonist. Taken together these findings suggest that low dose citalopram is useful for the treatment of memory deficits and consciousness disturbance.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalPharmacology Biochemistry and Behavior
Volume83
Issue number1
DOIs
Publication statusPublished - Jan 1 2006
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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