Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats

Kazuhiko Kubo, Okio Arai, Minoru Omura, Rumi Watanabe, Rika Ogata, Shuji Aou

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Abstract

There is an endocrinological concern that environmental endocrine disrupters (EEDs) may influence sexual differentiation. Bisphenol A (BPA), one of EEDs, is released from polycarbonate plastics, and has been detected in the human umbilical cord. In this study, we examined the effect of BPA on the sexual differentiation of open-field behavior and the sexually dimorphic nuclei in the brain in the offspring of rats exposed to BPA during the fetal and suckling periods at a dosage below the human tolerable daily intake (TDI) level. In the control group, females were more active in the open field and had a larger locus coeruleus (LC) volume than males. BPA abolished and inverted the sex differences of the open-field behavior and the LC volume, respectively, without affecting the reproductive system. We also compared the effects of estrogenic compounds, diethylstilbestrol (DES) and resveratrol (RVT), to that of BPA because of their structural similarities. DES affected the open-field behavior, LC volume and reproductive system, while RVT affected the LC volume and the reproductive system. These results suggest that the brain is highly sensitive to BPA at a dosage below TDI and that the disrupting effects of BPA on sexual differentiation may vary from those of RVT and DES.

Original languageEnglish
Pages (from-to)345-356
Number of pages12
JournalNeuroscience Research
Volume45
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

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Sex Differentiation
Sexual Behavior
Locus Coeruleus
Brain
Diethylstilbestrol
No-Observed-Adverse-Effect Level
Umbilical Cord
bisphenol A
Sex Characteristics
Estrogens
Control Groups
resveratrol

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats. / Kubo, Kazuhiko; Arai, Okio; Omura, Minoru; Watanabe, Rumi; Ogata, Rika; Aou, Shuji.

In: Neuroscience Research, Vol. 45, No. 3, 01.03.2003, p. 345-356.

Research output: Contribution to journalArticle

Kubo, Kazuhiko ; Arai, Okio ; Omura, Minoru ; Watanabe, Rumi ; Ogata, Rika ; Aou, Shuji. / Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats. In: Neuroscience Research. 2003 ; Vol. 45, No. 3. pp. 345-356.
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