Low HDL-cholesterol, hypertension and impaired glucose tolerance as predictors of acute myocardial infarction in northern area of Japan.

Naotsugu Oyama, Ichiro Sakuma, Noriaki Kishimoto, Yasuaki Saijo, Hidetsugu Sakai, Kazushi Urasawa, Akira Kitabatake, Reiko Kishi, Hiroyuki Tsutsui

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2 Citations (Scopus)

Abstract

Acute myocardial infarction (AMI) has gradually been increasing in Japan; however, since the burden of Japanese residents for risk factors (RFs) of AMI, such as hypercholesterolemia, is chronologically less accumulated compared with American and European people, their RFs of AMI may be different from those in western countries. To answer this question, a retrospective community-based study was carried out enrolling 722 first time AMI patients in Hokkaido, the northern island of Japan. As controls, 1748 age-, sex- and residence-matched subjects were randomly chosen from a data-base of a health check-up organization. We assessed associations between premorbid variables and the RFs for AMI. In men, the most important predictor reflected by high odds ratio (OR) was low HDL-cholesterol (HDL-C). Hypertension (HT) and impaired glucose tolerance (IGT) were also independent RFs. In women, HT represented the highest OR, and low HDL-C, high triglyceride (TG) and IGT followed. Total cholesterol (TC) was a negative predictor for AMI in both sexes, because mean TC level of AMI patients was less than that of controls probably because of acute phase reaction. Thus, low HDL-C, HT, IGT and high TG, which represent the state of metabolic syndrome, were important predictors of AMI. And it was suggested that low HDL-C plays a pivotal role in a population whose TC level is not high.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
Journal[Hokkaido igaku zasshi] The Hokkaido journal of medical science
Volume81
Issue number1
Publication statusPublished - Jan 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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