Lower activity of CCAAT/enhancer-binding protein and expression of cyclin E, but not cyclin D1, activating protein-1 and p21WAF1, after partial hepatectomy in obstructive jaundice

K. Nakano, K. Chijiiwa, M. Tanaka

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    22 Citations (Scopus)

    Abstract

    CCAAT/enhancer-binding protein (C/EBP)-α stabilizes p21WAF1, whereas activating protein-1 (AP-1) and C/EBP-β enhance cyclin D1 and cyclin E expression, respectively, during the progress of liver regeneration. In this study, we investigated the differences in the transcription factors and cell cycle regulators between obstructive jaundiced and control rats before and after hepatectomy accompanied with a release of biliary obstruction by internal biliary drainage. The expressions and activities of C/EBP-α and -β were significantly decreased in the jaundiced group concomitant with the significantly lower cyclin E expression after hepatectomy than in the controls. The activities of AP-1, cyclin D1 and p21WAF1 were not significantly different between the two groups. These results suggest that obstructive jaundice inhibits hepatic expression and activity of C/EBP, resulting in the impaired cyclin E expression that is partly responsible for the cell cycle dysfunction after hepatectomy.

    Original languageEnglish
    Pages (from-to)640-645
    Number of pages6
    JournalBiochemical and Biophysical Research Communications
    Volume280
    Issue number3
    DOIs
    Publication statusPublished - 2001

    All Science Journal Classification (ASJC) codes

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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