Lower activity of CCAAT/enhancer-binding protein and expression of cyclin E, but not cyclin D1, activating protein-1 and p21WAF1, after partial hepatectomy in obstructive jaundice

K. Nakano, K. Chijiiwa, M. Tanaka

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    21 Citations (Scopus)

    Abstract

    CCAAT/enhancer-binding protein (C/EBP)-α stabilizes p21WAF1, whereas activating protein-1 (AP-1) and C/EBP-β enhance cyclin D1 and cyclin E expression, respectively, during the progress of liver regeneration. In this study, we investigated the differences in the transcription factors and cell cycle regulators between obstructive jaundiced and control rats before and after hepatectomy accompanied with a release of biliary obstruction by internal biliary drainage. The expressions and activities of C/EBP-α and -β were significantly decreased in the jaundiced group concomitant with the significantly lower cyclin E expression after hepatectomy than in the controls. The activities of AP-1, cyclin D1 and p21WAF1 were not significantly different between the two groups. These results suggest that obstructive jaundice inhibits hepatic expression and activity of C/EBP, resulting in the impaired cyclin E expression that is partly responsible for the cell cycle dysfunction after hepatectomy.

    Original languageEnglish
    Pages (from-to)640-645
    Number of pages6
    JournalBiochemical and Biophysical Research Communications
    Volume280
    Issue number3
    DOIs
    Publication statusPublished - Jan 1 2001

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    CCAAT-Enhancer-Binding Proteins
    Cyclin E
    Obstructive Jaundice
    Cyclin D1
    Hepatectomy
    Cell Cycle
    Proteins
    Cells
    Rat control
    Liver Regeneration
    Jaundice
    Liver
    Drainage
    Transcription Factors

    All Science Journal Classification (ASJC) codes

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

    Cite this

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    title = "Lower activity of CCAAT/enhancer-binding protein and expression of cyclin E, but not cyclin D1, activating protein-1 and p21WAF1, after partial hepatectomy in obstructive jaundice",
    abstract = "CCAAT/enhancer-binding protein (C/EBP)-α stabilizes p21WAF1, whereas activating protein-1 (AP-1) and C/EBP-β enhance cyclin D1 and cyclin E expression, respectively, during the progress of liver regeneration. In this study, we investigated the differences in the transcription factors and cell cycle regulators between obstructive jaundiced and control rats before and after hepatectomy accompanied with a release of biliary obstruction by internal biliary drainage. The expressions and activities of C/EBP-α and -β were significantly decreased in the jaundiced group concomitant with the significantly lower cyclin E expression after hepatectomy than in the controls. The activities of AP-1, cyclin D1 and p21WAF1 were not significantly different between the two groups. These results suggest that obstructive jaundice inhibits hepatic expression and activity of C/EBP, resulting in the impaired cyclin E expression that is partly responsible for the cell cycle dysfunction after hepatectomy.",
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    TY - JOUR

    T1 - Lower activity of CCAAT/enhancer-binding protein and expression of cyclin E, but not cyclin D1, activating protein-1 and p21WAF1, after partial hepatectomy in obstructive jaundice

    AU - Nakano, K.

    AU - Chijiiwa, K.

    AU - Tanaka, M.

    PY - 2001/1/1

    Y1 - 2001/1/1

    N2 - CCAAT/enhancer-binding protein (C/EBP)-α stabilizes p21WAF1, whereas activating protein-1 (AP-1) and C/EBP-β enhance cyclin D1 and cyclin E expression, respectively, during the progress of liver regeneration. In this study, we investigated the differences in the transcription factors and cell cycle regulators between obstructive jaundiced and control rats before and after hepatectomy accompanied with a release of biliary obstruction by internal biliary drainage. The expressions and activities of C/EBP-α and -β were significantly decreased in the jaundiced group concomitant with the significantly lower cyclin E expression after hepatectomy than in the controls. The activities of AP-1, cyclin D1 and p21WAF1 were not significantly different between the two groups. These results suggest that obstructive jaundice inhibits hepatic expression and activity of C/EBP, resulting in the impaired cyclin E expression that is partly responsible for the cell cycle dysfunction after hepatectomy.

    AB - CCAAT/enhancer-binding protein (C/EBP)-α stabilizes p21WAF1, whereas activating protein-1 (AP-1) and C/EBP-β enhance cyclin D1 and cyclin E expression, respectively, during the progress of liver regeneration. In this study, we investigated the differences in the transcription factors and cell cycle regulators between obstructive jaundiced and control rats before and after hepatectomy accompanied with a release of biliary obstruction by internal biliary drainage. The expressions and activities of C/EBP-α and -β were significantly decreased in the jaundiced group concomitant with the significantly lower cyclin E expression after hepatectomy than in the controls. The activities of AP-1, cyclin D1 and p21WAF1 were not significantly different between the two groups. These results suggest that obstructive jaundice inhibits hepatic expression and activity of C/EBP, resulting in the impaired cyclin E expression that is partly responsible for the cell cycle dysfunction after hepatectomy.

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