Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome

Takashi Yokota, Shintaro Kinugawa, Koichi Okita, Kagami Hirabayashi, Tadashi Suga, Masaaki Hattori, Yoshinao Nakagawa, Noriko Oyama-Manabe, Hiroki Shirato, Hiroyuki Tsutsui

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Lower aerobic capacity is a strong and independent predictor of cardiovascular morbidity and mortality in patients with metabolic syndrome (MetS). However, the mechanisms are not fully elucidated. We tested the hypothesis that skeletal muscle dysfunction could contribute to the lower aerobic capacity in MetS patients. The incremental exercise tests with cycle ergometer were performed in 12 male patients with MetS with no habitual exercise and 11 age-, sex-and activity-matched control subjects to assess the aerobic capacity. We performed 31 phosphorus-magnetic resonance spectroscopy (MRS) to assess the high-energy phosphate metabolism in skeletal muscle during aerobic exercise. Proton-MRS was also performed to measure intramyocellular lipid (IMCL) content. Peak oxygen uptake (peak VO 2; 34.1±6.2 vs. 41.4±8.4 ml kg -1 min -1, P<0.05) and anaerobic threshold (AT; 18.0±2.4 vs. 23.1±3.7 ml kg -1 min -1, P<0.01) adjusted by lean body mass were lower in MetS patients than control subjects. Phosphocreatine (PCr) loss during exercise was 1.5-fold greater in MetS, suggesting reduced intramuscular oxidative capacity. PCr loss was inversely correlated with peak VO 2 (r=-0.64) and AT (r=-0.60), respectively. IMCL content was threefold higher in MetS and was inversely correlated with peak VO 2 (r=-0.47) and AT (r=-0.52), respectively. Moreover, there was a positive correlation between IMCL content and PCr loss (r=-0.64). These results suggested that lean-body aerobic capacity in MetS patients was lower compared with activity-matched healthy subjects, which might be due to the reduced intramuscular fatty acid oxidative metabolism.

Original languageEnglish
Pages (from-to)1029-1034
Number of pages6
JournalHypertension Research
Volume34
Issue number9
DOIs
Publication statusPublished - Sep 1 2011
Externally publishedYes

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Phosphocreatine
Exercise
Lipids
Skeletal Muscle
Anaerobic Threshold
Exercise Test
Phosphorus
Energy Metabolism
Healthy Volunteers
Magnetic Resonance Spectroscopy
Fatty Acids
Phosphates
Oxygen
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome. / Yokota, Takashi; Kinugawa, Shintaro; Okita, Koichi; Hirabayashi, Kagami; Suga, Tadashi; Hattori, Masaaki; Nakagawa, Yoshinao; Oyama-Manabe, Noriko; Shirato, Hiroki; Tsutsui, Hiroyuki.

In: Hypertension Research, Vol. 34, No. 9, 01.09.2011, p. 1029-1034.

Research output: Contribution to journalArticle

Yokota, T, Kinugawa, S, Okita, K, Hirabayashi, K, Suga, T, Hattori, M, Nakagawa, Y, Oyama-Manabe, N, Shirato, H & Tsutsui, H 2011, 'Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome', Hypertension Research, vol. 34, no. 9, pp. 1029-1034. https://doi.org/10.1038/hr.2011.78
Yokota, Takashi ; Kinugawa, Shintaro ; Okita, Koichi ; Hirabayashi, Kagami ; Suga, Tadashi ; Hattori, Masaaki ; Nakagawa, Yoshinao ; Oyama-Manabe, Noriko ; Shirato, Hiroki ; Tsutsui, Hiroyuki. / Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome. In: Hypertension Research. 2011 ; Vol. 34, No. 9. pp. 1029-1034.
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