Lower high-density lipoprotein cholesterol is a significant and independent risk for coronary artery disease in Japanese men.

Hiroki Satoh, Kazuo Tomita, Satoshi Fujii, Reiko Kishi, Hiroyuki Tsutsui

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

AIM: Lower levels of high-density lipoprotein cholesterol (HDL-C) have been recognized as a risk factor for coronary artery disease (CAD), but the relationship between HDL-C values and the occurrence of CAD has not been fully established in the Japanese general population. METHODS: A cohort study of 5,371 Japanese men with 12 years of follow-up was conducted to identify risk factors for the occurrence of CAD. RESULTS: One hundred and twelve subjects had CAD (acute myocardial infarction in 67 patients and angina in 45 patients) during the follow-up period. Adjustment for variables including age, body mass index, smoking habit, alcohol intake, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, fasting plasma glucose, hypertension, diabetes mellitus and hyperlipidemia, adjusted hazard ratio (HR) of lower levels of HDL-C for the occurrence of CAD was 1.21 (95% confidence interval (CI): 1.11-1.33, p<0.001). Serum HDL-C concentration less than 51 mg/dL was a significant risk for CAD. CONCLUSIONS: Low HDL-C was identified as a significant and independent risk for CAD in Japanese men using long-term follow-up data.

Original languageEnglish
Pages (from-to)792-798
Number of pages7
JournalJournal of atherosclerosis and thrombosis
Volume16
Issue number6
Publication statusPublished - Jan 1 2009
Externally publishedYes

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HDL Cholesterol
Coronary Artery Disease
LDL Cholesterol
Blood Pressure
Blood pressure
Medical problems
Hyperlipidemias
Habits
Fasting
Hazards
Diabetes Mellitus
Triglycerides
Body Mass Index
Cohort Studies
Smoking
Myocardial Infarction
Alcohols
Confidence Intervals
Hypertension
Plasmas

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Cite this

Lower high-density lipoprotein cholesterol is a significant and independent risk for coronary artery disease in Japanese men. / Satoh, Hiroki; Tomita, Kazuo; Fujii, Satoshi; Kishi, Reiko; Tsutsui, Hiroyuki.

In: Journal of atherosclerosis and thrombosis, Vol. 16, No. 6, 01.01.2009, p. 792-798.

Research output: Contribution to journalArticle

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AU - Satoh, Hiroki

AU - Tomita, Kazuo

AU - Fujii, Satoshi

AU - Kishi, Reiko

AU - Tsutsui, Hiroyuki

PY - 2009/1/1

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N2 - AIM: Lower levels of high-density lipoprotein cholesterol (HDL-C) have been recognized as a risk factor for coronary artery disease (CAD), but the relationship between HDL-C values and the occurrence of CAD has not been fully established in the Japanese general population. METHODS: A cohort study of 5,371 Japanese men with 12 years of follow-up was conducted to identify risk factors for the occurrence of CAD. RESULTS: One hundred and twelve subjects had CAD (acute myocardial infarction in 67 patients and angina in 45 patients) during the follow-up period. Adjustment for variables including age, body mass index, smoking habit, alcohol intake, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, fasting plasma glucose, hypertension, diabetes mellitus and hyperlipidemia, adjusted hazard ratio (HR) of lower levels of HDL-C for the occurrence of CAD was 1.21 (95% confidence interval (CI): 1.11-1.33, p<0.001). Serum HDL-C concentration less than 51 mg/dL was a significant risk for CAD. CONCLUSIONS: Low HDL-C was identified as a significant and independent risk for CAD in Japanese men using long-term follow-up data.

AB - AIM: Lower levels of high-density lipoprotein cholesterol (HDL-C) have been recognized as a risk factor for coronary artery disease (CAD), but the relationship between HDL-C values and the occurrence of CAD has not been fully established in the Japanese general population. METHODS: A cohort study of 5,371 Japanese men with 12 years of follow-up was conducted to identify risk factors for the occurrence of CAD. RESULTS: One hundred and twelve subjects had CAD (acute myocardial infarction in 67 patients and angina in 45 patients) during the follow-up period. Adjustment for variables including age, body mass index, smoking habit, alcohol intake, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, fasting plasma glucose, hypertension, diabetes mellitus and hyperlipidemia, adjusted hazard ratio (HR) of lower levels of HDL-C for the occurrence of CAD was 1.21 (95% confidence interval (CI): 1.11-1.33, p<0.001). Serum HDL-C concentration less than 51 mg/dL was a significant risk for CAD. CONCLUSIONS: Low HDL-C was identified as a significant and independent risk for CAD in Japanese men using long-term follow-up data.

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