Lower high-density lipoprotein cholesterol is a significant and independent risk for coronary artery disease in Japanese men.

Hiroki Satoh, Kazuo Tomita, Satoshi Fujii, Reiko Kishi, Hiroyuki Tsutsui

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

AIM: Lower levels of high-density lipoprotein cholesterol (HDL-C) have been recognized as a risk factor for coronary artery disease (CAD), but the relationship between HDL-C values and the occurrence of CAD has not been fully established in the Japanese general population. METHODS: A cohort study of 5,371 Japanese men with 12 years of follow-up was conducted to identify risk factors for the occurrence of CAD. RESULTS: One hundred and twelve subjects had CAD (acute myocardial infarction in 67 patients and angina in 45 patients) during the follow-up period. Adjustment for variables including age, body mass index, smoking habit, alcohol intake, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, fasting plasma glucose, hypertension, diabetes mellitus and hyperlipidemia, adjusted hazard ratio (HR) of lower levels of HDL-C for the occurrence of CAD was 1.21 (95% confidence interval (CI): 1.11-1.33, p<0.001). Serum HDL-C concentration less than 51 mg/dL was a significant risk for CAD. CONCLUSIONS: Low HDL-C was identified as a significant and independent risk for CAD in Japanese men using long-term follow-up data.

Original languageEnglish
Pages (from-to)792-798
Number of pages7
JournalJournal of atherosclerosis and thrombosis
Volume16
Issue number6
DOIs
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

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