Lower levels of high-density lipoprotein cholesterol on admission and a recurrence of ischemic stroke: A 12-month follow-up of the Fukuoka Stroke Registry

Takahiro Kuwashiro, Hiroshi Sugimori, Masahiro Kamouchi, Tetsuro Ago, Takanari Kitazono, Mitsuo Iida

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Despite recent progress in treatments for secondary prevention, ischemic stroke recurs in 8% to 12% of stroke survivors. We investigated the predisposing factors associated with recurrence within the first 12 months after an ischemic event to explore more effective preventive strategies. Methods: Between June 2007 and April 2008, acute (within 7 days of onset) ischemic stroke patients were registered in the Fukuoka Stroke Registry (FSR), a multicenter, prospective, observational database. The clinical characteristics on admission were analyzed, and the patients were followed for 12 months. Results: Two hundred sixty patients (151 males and 109 females, 71 ± 11 years of age) were registered; 25 (9.6%) had recurrence of ischemic stroke during the follow-up period. Kaplan-Meier curve analysis revealed a significant difference in recurrence-free survival between patients with high-density lipoprotein (HDL) cholesterol <40 mg/dL on admission and those with HDL cholesterol ≥40 mg/dL (P =.042). Adjusted multivariate logistic regression analysis showed that age (odds ratio 1.06; 95% CI, 1.00-1.11; P =.035) and HDL cholesterol <40 mg/dL (odds ratio 2.73; 95% CI, 1.01-7.38; P =.048) on admission were independently associated with a recurrence of ischemic stroke within 12 months of the initial onset. Conclusions: Aging and low HDL cholesterol levels are considered independent risk factors for a recurrence of ischemic stroke.

Original languageEnglish
Pages (from-to)561-568
Number of pages8
JournalJournal of Stroke and Cerebrovascular Diseases
Volume21
Issue number7
DOIs
Publication statusPublished - Oct 1 2012

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compound A 12
HDL Cholesterol
Registries
Stroke
Recurrence
Odds Ratio
Kaplan-Meier Estimate
Secondary Prevention
Causality
LDL Cholesterol
Survivors
Logistic Models
Regression Analysis
Databases
Survival

All Science Journal Classification (ASJC) codes

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

@article{c1ecc7833ec14a3ea60cee21b32165fa,
title = "Lower levels of high-density lipoprotein cholesterol on admission and a recurrence of ischemic stroke: A 12-month follow-up of the Fukuoka Stroke Registry",
abstract = "Background: Despite recent progress in treatments for secondary prevention, ischemic stroke recurs in 8{\%} to 12{\%} of stroke survivors. We investigated the predisposing factors associated with recurrence within the first 12 months after an ischemic event to explore more effective preventive strategies. Methods: Between June 2007 and April 2008, acute (within 7 days of onset) ischemic stroke patients were registered in the Fukuoka Stroke Registry (FSR), a multicenter, prospective, observational database. The clinical characteristics on admission were analyzed, and the patients were followed for 12 months. Results: Two hundred sixty patients (151 males and 109 females, 71 ± 11 years of age) were registered; 25 (9.6{\%}) had recurrence of ischemic stroke during the follow-up period. Kaplan-Meier curve analysis revealed a significant difference in recurrence-free survival between patients with high-density lipoprotein (HDL) cholesterol <40 mg/dL on admission and those with HDL cholesterol ≥40 mg/dL (P =.042). Adjusted multivariate logistic regression analysis showed that age (odds ratio 1.06; 95{\%} CI, 1.00-1.11; P =.035) and HDL cholesterol <40 mg/dL (odds ratio 2.73; 95{\%} CI, 1.01-7.38; P =.048) on admission were independently associated with a recurrence of ischemic stroke within 12 months of the initial onset. Conclusions: Aging and low HDL cholesterol levels are considered independent risk factors for a recurrence of ischemic stroke.",
author = "Takahiro Kuwashiro and Hiroshi Sugimori and Masahiro Kamouchi and Tetsuro Ago and Takanari Kitazono and Mitsuo Iida",
year = "2012",
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TY - JOUR

T1 - Lower levels of high-density lipoprotein cholesterol on admission and a recurrence of ischemic stroke

T2 - A 12-month follow-up of the Fukuoka Stroke Registry

AU - Kuwashiro, Takahiro

AU - Sugimori, Hiroshi

AU - Kamouchi, Masahiro

AU - Ago, Tetsuro

AU - Kitazono, Takanari

AU - Iida, Mitsuo

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Background: Despite recent progress in treatments for secondary prevention, ischemic stroke recurs in 8% to 12% of stroke survivors. We investigated the predisposing factors associated with recurrence within the first 12 months after an ischemic event to explore more effective preventive strategies. Methods: Between June 2007 and April 2008, acute (within 7 days of onset) ischemic stroke patients were registered in the Fukuoka Stroke Registry (FSR), a multicenter, prospective, observational database. The clinical characteristics on admission were analyzed, and the patients were followed for 12 months. Results: Two hundred sixty patients (151 males and 109 females, 71 ± 11 years of age) were registered; 25 (9.6%) had recurrence of ischemic stroke during the follow-up period. Kaplan-Meier curve analysis revealed a significant difference in recurrence-free survival between patients with high-density lipoprotein (HDL) cholesterol <40 mg/dL on admission and those with HDL cholesterol ≥40 mg/dL (P =.042). Adjusted multivariate logistic regression analysis showed that age (odds ratio 1.06; 95% CI, 1.00-1.11; P =.035) and HDL cholesterol <40 mg/dL (odds ratio 2.73; 95% CI, 1.01-7.38; P =.048) on admission were independently associated with a recurrence of ischemic stroke within 12 months of the initial onset. Conclusions: Aging and low HDL cholesterol levels are considered independent risk factors for a recurrence of ischemic stroke.

AB - Background: Despite recent progress in treatments for secondary prevention, ischemic stroke recurs in 8% to 12% of stroke survivors. We investigated the predisposing factors associated with recurrence within the first 12 months after an ischemic event to explore more effective preventive strategies. Methods: Between June 2007 and April 2008, acute (within 7 days of onset) ischemic stroke patients were registered in the Fukuoka Stroke Registry (FSR), a multicenter, prospective, observational database. The clinical characteristics on admission were analyzed, and the patients were followed for 12 months. Results: Two hundred sixty patients (151 males and 109 females, 71 ± 11 years of age) were registered; 25 (9.6%) had recurrence of ischemic stroke during the follow-up period. Kaplan-Meier curve analysis revealed a significant difference in recurrence-free survival between patients with high-density lipoprotein (HDL) cholesterol <40 mg/dL on admission and those with HDL cholesterol ≥40 mg/dL (P =.042). Adjusted multivariate logistic regression analysis showed that age (odds ratio 1.06; 95% CI, 1.00-1.11; P =.035) and HDL cholesterol <40 mg/dL (odds ratio 2.73; 95% CI, 1.01-7.38; P =.048) on admission were independently associated with a recurrence of ischemic stroke within 12 months of the initial onset. Conclusions: Aging and low HDL cholesterol levels are considered independent risk factors for a recurrence of ischemic stroke.

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SN - 1052-3057

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