Lowered entrainment function in the suprachiasmatic nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) rats

Takao Shimazoe, Miyuki Maetani, Sachiko Nakamura, Shiro Yamanouchi, Shigenori Watanabe, Kyoko Miyasaka, Akira Kono, Akihiro Funakoshi

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Abstract

The entrainment function in the suprachiasmatic nucleus (SCN) of young non-diabetic Otsuka Long Evans Tokushima Fatty (OLETF) rats was studied. OLETF rats significantly needed more days for re-entrainment to a new light-dark cycle than control Long Evans Tokushima Otsuka (LETO) rats. We also assessed Fos expression in the SCN induced by dim light exposure. The number of Fos-immunoreactive cells was significantly decreased in 5- to 13-week-old OLETF rats compared with LETO rats. Moreover, the effect of glutamate on neuronal activity in the SCN of OLETF rats were investigated. In young non-diabetic OLETF rats, the phase delay in the SCN neuronal firing rhythm induced by 1 μM glutamate was significantly less than that in LETO rats. These results suggested that the entrainment function is reduced in OLETF rats before the onset of diabetes.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalJapanese Journal of Pharmacology
Volume80
Issue number1
DOIs
Publication statusPublished - Jun 22 1999

All Science Journal Classification (ASJC) codes

  • Pharmacology

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    Shimazoe, T., Maetani, M., Nakamura, S., Yamanouchi, S., Watanabe, S., Miyasaka, K., Kono, A., & Funakoshi, A. (1999). Lowered entrainment function in the suprachiasmatic nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) rats. Japanese Journal of Pharmacology, 80(1), 85-88. https://doi.org/10.1254/jjp.80.85