lpr T cells have lower ability to maintain bcl-2 expression ex vivo

Y. Matsumoto, T. Shinzato, I. Takai, Y. Kimura, S. Nakai, M. Miwa, K. Fuse, Y. Yoshikai, K. Maeda

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    Abstract

    Autoimmune-prone lpr mice develop lymphoproliferative disorders, whereas their lymphocytes show accelerated apoptosis in culture. To elucidate whether the bcl-2 protein, a repressor of apoptosis, is critical to the discrepancy between in vivo and in vitro survival, we examined bcl-2 expression in T cells from +/+ and lpr mice during culture. The expression levels of bcl-2 in cultured T cells from lpr mice were significantly down-modulated compared to those from +/+ mice and freshly obtained T cells. Besides, the reduction of bcl-2 protein levels was inhibited in T cells cultured in the presence of T cell receptor (TCR) signalling. These results suggest that lpr T cells might be susceptible to apoptosis in vitro due to down-modulation of bcl-2 by withdrawal of TCR signalling.

    Original languageEnglish
    Pages (from-to)283-288
    Number of pages6
    JournalApoptosis
    Volume2
    Issue number3
    DOIs
    Publication statusPublished - Jan 1 1997

    All Science Journal Classification (ASJC) codes

    • Pharmacology
    • Pharmaceutical Science
    • Clinical Biochemistry
    • Cell Biology
    • Biochemistry, medical
    • Cancer Research

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