Lugol stain for intraoperative determination of the proximal surgical margin of the esophagus

Keizo Sugimachi, Shinichi Tsutsui, Kaoru Kitamura, Masaru Morita, Masaki Mori, Hiroyuki Kuwano

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

An adequate proximal surgical margin is difficult to determine particularly in cases of esophageal carcinoma with surrounding intraepithelial invasion. We report here readily facilitated intraoperative approaches for detection of the exact margin of carcinomatous invasion of the esophagus. The resected specimen of the esophagus is incised longitudinally and placed in a 1% Lugol bath for 2–3 minutes. The normal squamous epithelium includes glycogen that interacts with the iodine of Lugol's solution and the normal epithelium of the esophagus becomes a uniform greenish‐brown. A squamous cell carcinoma does not include glycogen, hence is not stained with this solution and a clear identification is feasible. Thus, a carcinomatous infiltration not recognizable in routine examinations becomes macroscopically visible when Lugol's solution is used.

Original languageEnglish
Pages (from-to)226-229
Number of pages4
JournalJournal of Surgical Oncology
Volume46
Issue number4
DOIs
Publication statusPublished - Apr 1991

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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