Luminescent europium sensors for specific detection of 8-oxo-dGTP by time-gated fluorescence

Yasufumi Fuchi, Takashi Fukuda, Shigeki Sasaki

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The 9-hydroxy-1,3-diazaphenoxazine-2-one unit was conjugated with the Eu3+-cyclen complex through a linker. This diazaphenoxazine group was expected as an antenna unit for the excitation of europium ion, and a selective recognition site for 8-oxo-dGTP base. Among the synthesized three derivatives, the highest fluorescence emission was obtained by the complex constructed of an ethylene linker and the cyclen unit with three N,N-dimethylacetamide groups. The Eu3+-cyclen complex exhibited a selective response to the 8-oxo-dGTP in aqueous media by a time-resolved fluorescence assay.

Original languageEnglish
Pages (from-to)3254-3260
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume26
Issue number12
DOIs
Publication statusPublished - Jul 23 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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