Abstract
The 9-hydroxy-1,3-diazaphenoxazine-2-one unit was conjugated with the Eu3+-cyclen complex through a linker. This diazaphenoxazine group was expected as an antenna unit for the excitation of europium ion, and a selective recognition site for 8-oxo-dGTP base. Among the synthesized three derivatives, the highest fluorescence emission was obtained by the complex constructed of an ethylene linker and the cyclen unit with three N,N-dimethylacetamide groups. The Eu3+-cyclen complex exhibited a selective response to the 8-oxo-dGTP in aqueous media by a time-resolved fluorescence assay.
| Original language | English |
|---|---|
| Pages (from-to) | 3254-3260 |
| Number of pages | 7 |
| Journal | Bioorganic and Medicinal Chemistry |
| Volume | 26 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Jul 23 2018 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
Cite this
Luminescent europium sensors for specific detection of 8-oxo-dGTP by time-gated fluorescence. / Fuchi, Yasufumi; Fukuda, Takashi; Sasaki, Shigeki.
In: Bioorganic and Medicinal Chemistry, Vol. 26, No. 12, 23.07.2018, p. 3254-3260.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Luminescent europium sensors for specific detection of 8-oxo-dGTP by time-gated fluorescence
AU - Fuchi, Yasufumi
AU - Fukuda, Takashi
AU - Sasaki, Shigeki
PY - 2018/7/23
Y1 - 2018/7/23
N2 - The 9-hydroxy-1,3-diazaphenoxazine-2-one unit was conjugated with the Eu3+-cyclen complex through a linker. This diazaphenoxazine group was expected as an antenna unit for the excitation of europium ion, and a selective recognition site for 8-oxo-dGTP base. Among the synthesized three derivatives, the highest fluorescence emission was obtained by the complex constructed of an ethylene linker and the cyclen unit with three N,N-dimethylacetamide groups. The Eu3+-cyclen complex exhibited a selective response to the 8-oxo-dGTP in aqueous media by a time-resolved fluorescence assay.
AB - The 9-hydroxy-1,3-diazaphenoxazine-2-one unit was conjugated with the Eu3+-cyclen complex through a linker. This diazaphenoxazine group was expected as an antenna unit for the excitation of europium ion, and a selective recognition site for 8-oxo-dGTP base. Among the synthesized three derivatives, the highest fluorescence emission was obtained by the complex constructed of an ethylene linker and the cyclen unit with three N,N-dimethylacetamide groups. The Eu3+-cyclen complex exhibited a selective response to the 8-oxo-dGTP in aqueous media by a time-resolved fluorescence assay.
UR - http://www.scopus.com/inward/record.url?scp=85046708488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046708488&partnerID=8YFLogxK
U2 - 10.1016/j.bmc.2018.04.052
DO - 10.1016/j.bmc.2018.04.052
M3 - Article
VL - 26
SP - 3254
EP - 3260
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
SN - 0968-0896
IS - 12
ER -