Lung adenocarcinoma with bronchioloalveolar carcinoma component is frequently associated with foci of high-grade atypical adenomatous hyperplasia

Takaomi Koga, Shuichi Hashimoto, Kenji Sugio, Yoshikazu Yonemitsu, Yutaka Nakashima, Ichiro Yoshino, Yoshio Matsuo, Sepideh Mojtahedzadeh, Keizo Sugimachi, Katsuo Sueishi

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Abstract

We assessed the occurrence of atypical adenomatous hyperplasia (AAH) in whole lung lobes with primary cancer lesions. Following surgical resection, tissue specimens were sliced to a thickness of 4 mm (3,641 specimens from 61 cases; mean = 59.7 specimens per case). A total of 119 AAH foci were found and an association was evident in 25 (57%) of 44 adenocarcinomas, 3 (30%) of 10 squamous cell carcinomas, and 2 (29%) of 7 other lung cancers. Histologic evaluation showed that 108 AAH foci were categorized as low-grade and the other 11 as high-grade AAH. These 11 foci of high-grade AAH were present in 7 patients with adenocarcinoma, and in 1 patient there was a synchronous double primary lung adenocarcinoma. High-grade AAH was closely associated with bronchioloalveolar carcinoma (BAC) type adenocarcinoma, and low-grade AAH with non-BAC adenocarcinoma. The mean ± SD Ki-67 labeling index in high-grade AAH (3.5% ± 2.9%) was significantly higher than for the low-grade index (1.4% ± 1.6%). We propose that foci of high- but not low-grade AAH may be potential precursor lesions of lung adenocarcinoma, especially with the BAC component.

Original languageEnglish
Pages (from-to)464-470
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume117
Issue number3
DOIs
Publication statusPublished - Mar 25 2002

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Bronchiolo-Alveolar Adenocarcinoma
Hyperplasia
Adenocarcinoma
Adenocarcinoma of lung
Squamous Cell Carcinoma
Lung Neoplasms
Carcinoma
Lung

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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Lung adenocarcinoma with bronchioloalveolar carcinoma component is frequently associated with foci of high-grade atypical adenomatous hyperplasia. / Koga, Takaomi; Hashimoto, Shuichi; Sugio, Kenji; Yonemitsu, Yoshikazu; Nakashima, Yutaka; Yoshino, Ichiro; Matsuo, Yoshio; Mojtahedzadeh, Sepideh; Sugimachi, Keizo; Sueishi, Katsuo.

In: American Journal of Clinical Pathology, Vol. 117, No. 3, 25.03.2002, p. 464-470.

Research output: Contribution to journalArticle

Koga, Takaomi ; Hashimoto, Shuichi ; Sugio, Kenji ; Yonemitsu, Yoshikazu ; Nakashima, Yutaka ; Yoshino, Ichiro ; Matsuo, Yoshio ; Mojtahedzadeh, Sepideh ; Sugimachi, Keizo ; Sueishi, Katsuo. / Lung adenocarcinoma with bronchioloalveolar carcinoma component is frequently associated with foci of high-grade atypical adenomatous hyperplasia. In: American Journal of Clinical Pathology. 2002 ; Vol. 117, No. 3. pp. 464-470.
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