Lung cancer: rational strategies for early detection and intervention.

J. L. Mulshine, A. M. Treston, F. M. Scott, I. Avis, C. Boland, R. Phelps, P. G. Kasprzyk, Y. Nakanishi, F. Cuttitta

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The current mortality rate for lung cancer, which approaches 90% at two years, is not decreasing despite intensive clinical trials attempting to improve systemic therapy. New drug discoveries and dose intensification approaches have not resulted in more effective anti-tumor control. An alternative approach using sputum immunocytology for early lung cancer detection was recently reported. The proposed basis for this early detection reflects the underlying biology of immunodominant carbohydrate tumor-associated antigens, which are recognized as a class of oncofetal antigens. The process of bronchial epithelial carcinogenesis is associated with an evolution of carbohydrate display which reverses the sequence originally associated with fetal organ development. By elucidating this pattern of fetal carbohydrate display, a precise map of stage of bronchial carcinogenesis may emerge.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalOncology (Williston Park, N.Y.)
Volume5
Issue number5
Publication statusPublished - May 1 1991

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Lung Neoplasms
Carcinogenesis
Tumor-Associated Carbohydrate Antigens
Carbohydrates
Drug Discovery
Fetal Development
Sputum
Early Detection of Cancer
Clinical Trials
Mortality
Neoplasms
Therapeutics
oncofetal antigens

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Mulshine, J. L., Treston, A. M., Scott, F. M., Avis, I., Boland, C., Phelps, R., ... Cuttitta, F. (1991). Lung cancer: rational strategies for early detection and intervention. Oncology (Williston Park, N.Y.), 5(5), 25-32.

Lung cancer : rational strategies for early detection and intervention. / Mulshine, J. L.; Treston, A. M.; Scott, F. M.; Avis, I.; Boland, C.; Phelps, R.; Kasprzyk, P. G.; Nakanishi, Y.; Cuttitta, F.

In: Oncology (Williston Park, N.Y.), Vol. 5, No. 5, 01.05.1991, p. 25-32.

Research output: Contribution to journalArticle

Mulshine, JL, Treston, AM, Scott, FM, Avis, I, Boland, C, Phelps, R, Kasprzyk, PG, Nakanishi, Y & Cuttitta, F 1991, 'Lung cancer: rational strategies for early detection and intervention.', Oncology (Williston Park, N.Y.), vol. 5, no. 5, pp. 25-32.
Mulshine JL, Treston AM, Scott FM, Avis I, Boland C, Phelps R et al. Lung cancer: rational strategies for early detection and intervention. Oncology (Williston Park, N.Y.). 1991 May 1;5(5):25-32.
Mulshine, J. L. ; Treston, A. M. ; Scott, F. M. ; Avis, I. ; Boland, C. ; Phelps, R. ; Kasprzyk, P. G. ; Nakanishi, Y. ; Cuttitta, F. / Lung cancer : rational strategies for early detection and intervention. In: Oncology (Williston Park, N.Y.). 1991 ; Vol. 5, No. 5. pp. 25-32.
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