Lung cancer risk and genetic polymorphisms in DNA repair pathways

A meta-analysis

Chikako Kiyohara, Koichi Takayama, Yoichi Nakanishi

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk. We conducted a meta-analysis of epidemiologic studies on the association between genetic polymorphisms in both base excision repair and nucleotide excision repair pathways, and lung cancer. We found xeroderma pigmentosum complementation group A (XPA) G23A (odds ratio (OR) = 0.76, 95% confidence interval (CI) = 0.61 -0.94), 8-oxoguanine DNA glycosylase 1 (OGG1) Ser326Cys (OR = 1.22, 95% CI = 1.02 -1.45), and excision repair cross-complementing group 2 (ERCC2) Lys751Gln (OR = 1.27, 95% CI = 1.10 -1.46) polymorphisms were associated with lung cancer risk. Considering the data available, it can be conjectured that if there is any risk association between a single SNP and lung cancer, the risk fluctuation will probably be minimal. Advances in the identification of new polymorphisms and in high-throughput genotyping techniques will facilitate the analysis of multiple genes in multiple DNA repair pathways. Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples of cases and controls.

Original languageEnglish
Article number701760
JournalJournal of Nucleic Acids
Volume2010
DOIs
Publication statusPublished - Dec 1 2010

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Genetic Polymorphisms
Polymorphism
DNA Repair
Meta-Analysis
Lung Neoplasms
Repair
DNA
Odds Ratio
Confidence Intervals
Epidemiologic Studies
Genotyping Techniques
Genes
DNA Glycosylases
Xeroderma Pigmentosum
Single Nucleotide Polymorphism
Nucleotides
Throughput

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Lung cancer risk and genetic polymorphisms in DNA repair pathways : A meta-analysis. / Kiyohara, Chikako; Takayama, Koichi; Nakanishi, Yoichi.

In: Journal of Nucleic Acids, Vol. 2010, 701760, 01.12.2010.

Research output: Contribution to journalReview article

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