Lung cancer surgery in patients aged 80 years or older: an analysis of risk factors, morbidity, and mortality

Naoko Miura, Mikihiro Kohno, Kensaku Ito, Mayuko Senba, Koutarou Kajiwara, Naohiko Hamaguchi, Hideki Makino, Takanori Kanematsu, Tatsuro Okamoto, Hideki Yokoyama

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Introduction: As the population ages, the age of patients undergoing thoracic surgery increases, and elderly patients often have more comorbidities than younger patients. Methods: This retrospective study observed preoperative comorbidities, surgical procedures and postoperative morbidity and mortality after lung cancer surgery in patients 80 years of age or older. The medical records of lung cancer patients 80 years of age or older who underwent surgery from January 2003 to December 2012 were reviewed. Results: There were 49 patients (27 males, 22 females), with a median age of 83 years. Thirty patients underwent major pulmonary resection and 18 patients underwent limited pulmonary resection. The median Charlson comorbidity index was 3. Although approximately two-thirds of the patients (20 patients; 40.8 %) experienced some kind of postoperative morbidity, more than 80 % of the complications were grade 1 or 2 according to the Clavien–Dindo classification. Cerebrovascular disease and chronic obstructive pulmonary disease were significantly associated with moderate-to-severe complications. Postoperative death was observed in two cases (4.1 %). In addition, an increased American Society of Anesthesiologists classification score and past history of myocardial infarction, congestive heart failure and/or diabetes mellitus with end-organ damage were significantly associated with mortality. The overall survival rate was 79.6 % at 3 years and 53.1 % at 5 years. Conclusions: Thoracic surgery shows acceptable morbidity and mortality in patients 80 years of age or older. Patients 80 years of age or older should be offered the best treatments, including surgery, with careful patient evaluation and selection.

Original languageEnglish
Pages (from-to)401-405
Number of pages5
JournalGeneral Thoracic and Cardiovascular Surgery
Volume63
Issue number7
DOIs
Publication statusPublished - Jul 22 2015

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Lung Neoplasms
Morbidity
Mortality
Comorbidity
Thoracic Surgery
Cerebrovascular Disorders
Lung
Postoperative Care
Chronic Obstructive Pulmonary Disease
Patient Selection
Medical Records
Diabetes Mellitus
Survival Rate
Heart Failure
Retrospective Studies
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Lung cancer surgery in patients aged 80 years or older : an analysis of risk factors, morbidity, and mortality. / Miura, Naoko; Kohno, Mikihiro; Ito, Kensaku; Senba, Mayuko; Kajiwara, Koutarou; Hamaguchi, Naohiko; Makino, Hideki; Kanematsu, Takanori; Okamoto, Tatsuro; Yokoyama, Hideki.

In: General Thoracic and Cardiovascular Surgery, Vol. 63, No. 7, 22.07.2015, p. 401-405.

Research output: Contribution to journalArticle

Miura, N, Kohno, M, Ito, K, Senba, M, Kajiwara, K, Hamaguchi, N, Makino, H, Kanematsu, T, Okamoto, T & Yokoyama, H 2015, 'Lung cancer surgery in patients aged 80 years or older: an analysis of risk factors, morbidity, and mortality', General Thoracic and Cardiovascular Surgery, vol. 63, no. 7, pp. 401-405. https://doi.org/10.1007/s11748-015-0546-7
Miura, Naoko ; Kohno, Mikihiro ; Ito, Kensaku ; Senba, Mayuko ; Kajiwara, Koutarou ; Hamaguchi, Naohiko ; Makino, Hideki ; Kanematsu, Takanori ; Okamoto, Tatsuro ; Yokoyama, Hideki. / Lung cancer surgery in patients aged 80 years or older : an analysis of risk factors, morbidity, and mortality. In: General Thoracic and Cardiovascular Surgery. 2015 ; Vol. 63, No. 7. pp. 401-405.
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AU - Miura, Naoko

AU - Kohno, Mikihiro

AU - Ito, Kensaku

AU - Senba, Mayuko

AU - Kajiwara, Koutarou

AU - Hamaguchi, Naohiko

AU - Makino, Hideki

AU - Kanematsu, Takanori

AU - Okamoto, Tatsuro

AU - Yokoyama, Hideki

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N2 - Introduction: As the population ages, the age of patients undergoing thoracic surgery increases, and elderly patients often have more comorbidities than younger patients. Methods: This retrospective study observed preoperative comorbidities, surgical procedures and postoperative morbidity and mortality after lung cancer surgery in patients 80 years of age or older. The medical records of lung cancer patients 80 years of age or older who underwent surgery from January 2003 to December 2012 were reviewed. Results: There were 49 patients (27 males, 22 females), with a median age of 83 years. Thirty patients underwent major pulmonary resection and 18 patients underwent limited pulmonary resection. The median Charlson comorbidity index was 3. Although approximately two-thirds of the patients (20 patients; 40.8 %) experienced some kind of postoperative morbidity, more than 80 % of the complications were grade 1 or 2 according to the Clavien–Dindo classification. Cerebrovascular disease and chronic obstructive pulmonary disease were significantly associated with moderate-to-severe complications. Postoperative death was observed in two cases (4.1 %). In addition, an increased American Society of Anesthesiologists classification score and past history of myocardial infarction, congestive heart failure and/or diabetes mellitus with end-organ damage were significantly associated with mortality. The overall survival rate was 79.6 % at 3 years and 53.1 % at 5 years. Conclusions: Thoracic surgery shows acceptable morbidity and mortality in patients 80 years of age or older. Patients 80 years of age or older should be offered the best treatments, including surgery, with careful patient evaluation and selection.

AB - Introduction: As the population ages, the age of patients undergoing thoracic surgery increases, and elderly patients often have more comorbidities than younger patients. Methods: This retrospective study observed preoperative comorbidities, surgical procedures and postoperative morbidity and mortality after lung cancer surgery in patients 80 years of age or older. The medical records of lung cancer patients 80 years of age or older who underwent surgery from January 2003 to December 2012 were reviewed. Results: There were 49 patients (27 males, 22 females), with a median age of 83 years. Thirty patients underwent major pulmonary resection and 18 patients underwent limited pulmonary resection. The median Charlson comorbidity index was 3. Although approximately two-thirds of the patients (20 patients; 40.8 %) experienced some kind of postoperative morbidity, more than 80 % of the complications were grade 1 or 2 according to the Clavien–Dindo classification. Cerebrovascular disease and chronic obstructive pulmonary disease were significantly associated with moderate-to-severe complications. Postoperative death was observed in two cases (4.1 %). In addition, an increased American Society of Anesthesiologists classification score and past history of myocardial infarction, congestive heart failure and/or diabetes mellitus with end-organ damage were significantly associated with mortality. The overall survival rate was 79.6 % at 3 years and 53.1 % at 5 years. Conclusions: Thoracic surgery shows acceptable morbidity and mortality in patients 80 years of age or older. Patients 80 years of age or older should be offered the best treatments, including surgery, with careful patient evaluation and selection.

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