Lung histopathological pattern in a survivor with rapidly progressive interstitial lung disease and anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis

Atsushi Suzuki; Yasuhiro Kondoh; Hiroyuki Taniguchi; Kazuhiko Tabata; Tomoki Kimura; Kensuke Kataoka; Kenzo Ono; Mikiko Hashisako; Junya Fukuoka

doi:10.1016/j.rmcr.2016.05.008

Lung histopathological pattern in a survivor with rapidly progressive interstitial lung disease and anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis

Atsushi Suzuki, Yasuhiro Kondoh, Hiroyuki Taniguchi, Kazuhiko Tabata, Tomoki Kimura, Kensuke Kataoka, Kenzo Ono, Mikiko Hashisako, Junya Fukuoka

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are specific indicators of patients with dermatomyositis, particularly clinically amyopathic dermatomyositis (CADM). CADM is occasionally accompanied by fatal, treatment-resistant, rapidly-progressive interstitial lung disease (RP-ILD). All previous reports showed that histopathological findings in RP-ILD with anti-MDA5 antibody-positive CADM indicated diffuse alveolar damage (DAD). This is the first report describing a non-DAD pattern in RP-ILD with anti-MDA5 antibody-positive CADM, which was improved by immunosuppressive therapy. This case may be a milder clinical phenotype than a typical DAD pattern in RP-ILD with anti-MDA5 antibody-positive CADM.

Original language	English
Pages (from-to)	5-8
Number of pages	4
Journal	Respiratory Medicine Case Reports
Volume	19
DOIs	https://doi.org/10.1016/j.rmcr.2016.05.008
Publication status	Published - 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pulmonary and Respiratory Medicine

Access to Document

10.1016/j.rmcr.2016.05.008

Cite this

Suzuki, A., Kondoh, Y., Taniguchi, H., Tabata, K., Kimura, T., Kataoka, K., Ono, K., Hashisako, M., & Fukuoka, J. (2016). Lung histopathological pattern in a survivor with rapidly progressive interstitial lung disease and anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis. Respiratory Medicine Case Reports, 19, 5-8. https://doi.org/10.1016/j.rmcr.2016.05.008

Lung histopathological pattern in a survivor with rapidly progressive interstitial lung disease and anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis. / Suzuki, Atsushi; Kondoh, Yasuhiro; Taniguchi, Hiroyuki et al.
In: Respiratory Medicine Case Reports, Vol. 19, 2016, p. 5-8.

Research output: Contribution to journal › Article › peer-review

Suzuki, A, Kondoh, Y, Taniguchi, H, Tabata, K, Kimura, T, Kataoka, K, Ono, K, Hashisako, M & Fukuoka, J 2016, 'Lung histopathological pattern in a survivor with rapidly progressive interstitial lung disease and anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis', Respiratory Medicine Case Reports, vol. 19, pp. 5-8. https://doi.org/10.1016/j.rmcr.2016.05.008

@article{c0fb0202a16d48d29bdb0d783bf16781,

title = "Lung histopathological pattern in a survivor with rapidly progressive interstitial lung disease and anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis",

abstract = "Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are specific indicators of patients with dermatomyositis, particularly clinically amyopathic dermatomyositis (CADM). CADM is occasionally accompanied by fatal, treatment-resistant, rapidly-progressive interstitial lung disease (RP-ILD). All previous reports showed that histopathological findings in RP-ILD with anti-MDA5 antibody-positive CADM indicated diffuse alveolar damage (DAD). This is the first report describing a non-DAD pattern in RP-ILD with anti-MDA5 antibody-positive CADM, which was improved by immunosuppressive therapy. This case may be a milder clinical phenotype than a typical DAD pattern in RP-ILD with anti-MDA5 antibody-positive CADM.",

author = "Atsushi Suzuki and Yasuhiro Kondoh and Hiroyuki Taniguchi and Kazuhiko Tabata and Tomoki Kimura and Kensuke Kataoka and Kenzo Ono and Mikiko Hashisako and Junya Fukuoka",

note = "Publisher Copyright: {\textcopyright} 2016 The Authors.",

year = "2016",

doi = "10.1016/j.rmcr.2016.05.008",

language = "English",

volume = "19",

pages = "5--8",

journal = "Respiratory Medicine Case Reports",

issn = "2213-0071",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Lung histopathological pattern in a survivor with rapidly progressive interstitial lung disease and anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis

AU - Suzuki, Atsushi

AU - Kondoh, Yasuhiro

AU - Taniguchi, Hiroyuki

AU - Tabata, Kazuhiko

AU - Kimura, Tomoki

AU - Kataoka, Kensuke

AU - Ono, Kenzo

AU - Hashisako, Mikiko

AU - Fukuoka, Junya

PY - 2016

Y1 - 2016

N2 - Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are specific indicators of patients with dermatomyositis, particularly clinically amyopathic dermatomyositis (CADM). CADM is occasionally accompanied by fatal, treatment-resistant, rapidly-progressive interstitial lung disease (RP-ILD). All previous reports showed that histopathological findings in RP-ILD with anti-MDA5 antibody-positive CADM indicated diffuse alveolar damage (DAD). This is the first report describing a non-DAD pattern in RP-ILD with anti-MDA5 antibody-positive CADM, which was improved by immunosuppressive therapy. This case may be a milder clinical phenotype than a typical DAD pattern in RP-ILD with anti-MDA5 antibody-positive CADM.

AB - Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are specific indicators of patients with dermatomyositis, particularly clinically amyopathic dermatomyositis (CADM). CADM is occasionally accompanied by fatal, treatment-resistant, rapidly-progressive interstitial lung disease (RP-ILD). All previous reports showed that histopathological findings in RP-ILD with anti-MDA5 antibody-positive CADM indicated diffuse alveolar damage (DAD). This is the first report describing a non-DAD pattern in RP-ILD with anti-MDA5 antibody-positive CADM, which was improved by immunosuppressive therapy. This case may be a milder clinical phenotype than a typical DAD pattern in RP-ILD with anti-MDA5 antibody-positive CADM.

UR - http://www.scopus.com/inward/record.url?scp=84973477598&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973477598&partnerID=8YFLogxK

U2 - 10.1016/j.rmcr.2016.05.008

DO - 10.1016/j.rmcr.2016.05.008

M3 - Article

AN - SCOPUS:84973477598

SN - 2213-0071

VL - 19

SP - 5

EP - 8

JO - Respiratory Medicine Case Reports

JF - Respiratory Medicine Case Reports

ER -

Lung histopathological pattern in a survivor with rapidly progressive interstitial lung disease and anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this