Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of α-glucosidase action

Toshiro Matsui, Mio Kobayashi, Sachiko Hayashida, Kiyoshi Matsumoto

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

In order to clarify the postprandial glucose suppression via α-glucosidase (AGH) inhibitory action by natural compounds, flavonoids were examined in this study. Among the flavonoids (luteolin, kaempferol, chrysin, and galangin), luteolin showed the potent maltase inhibitory activity with the IC50 of 2.3 mM, while less inhibitions were observed against sucrase. In addition, the effects of maltase inhibition by flavonoids were observed in the descending order of potency of luteolin>kaempferol>chrysin>galangin. Apparently, the AGH inhibition power greatly increased with the replacement of hydroxyl groups at 3′ and 4′-position of the B-ring. However, the inhibitory power of luteolin was poorer than a therapeutic drug (acarbose: IC50; 430 nM). As a result of a single oral administration of maltose or sucrose (2 g/kg) in SD rats, no significant change in blood glucose level with the doses of 100 and 200 mg/kg of luteolin was observed. These findings strongly suggested that luteolin given at less than 200 mg/kg did not possess the ability to suppress the glucose production from carbohydrates through the inhibition of AGH action in the gut.

Original languageEnglish
Pages (from-to)689-692
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume66
Issue number3
DOIs
Publication statusPublished - Jan 1 2002

Fingerprint

flavone
Glucosidases
Luteolin
Glucose
Flavonoids
alpha-Glucosidases
Inhibitory Concentration 50
Acarbose
Sucrase
Maltose
Hydroxyl Radical
Oral Administration
Sucrose
Blood Glucose
Rats
Carbohydrates

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of α-glucosidase action. / Matsui, Toshiro; Kobayashi, Mio; Hayashida, Sachiko; Matsumoto, Kiyoshi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 66, No. 3, 01.01.2002, p. 689-692.

Research output: Contribution to journalArticle

@article{52f274b9344f4ed280cbf38e1ed854dc,
title = "Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of α-glucosidase action",
abstract = "In order to clarify the postprandial glucose suppression via α-glucosidase (AGH) inhibitory action by natural compounds, flavonoids were examined in this study. Among the flavonoids (luteolin, kaempferol, chrysin, and galangin), luteolin showed the potent maltase inhibitory activity with the IC50 of 2.3 mM, while less inhibitions were observed against sucrase. In addition, the effects of maltase inhibition by flavonoids were observed in the descending order of potency of luteolin>kaempferol>chrysin>galangin. Apparently, the AGH inhibition power greatly increased with the replacement of hydroxyl groups at 3′ and 4′-position of the B-ring. However, the inhibitory power of luteolin was poorer than a therapeutic drug (acarbose: IC50; 430 nM). As a result of a single oral administration of maltose or sucrose (2 g/kg) in SD rats, no significant change in blood glucose level with the doses of 100 and 200 mg/kg of luteolin was observed. These findings strongly suggested that luteolin given at less than 200 mg/kg did not possess the ability to suppress the glucose production from carbohydrates through the inhibition of AGH action in the gut.",
author = "Toshiro Matsui and Mio Kobayashi and Sachiko Hayashida and Kiyoshi Matsumoto",
year = "2002",
month = "1",
day = "1",
doi = "10.1271/bbb.66.689",
language = "English",
volume = "66",
pages = "689--692",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "3",

}

TY - JOUR

T1 - Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of α-glucosidase action

AU - Matsui, Toshiro

AU - Kobayashi, Mio

AU - Hayashida, Sachiko

AU - Matsumoto, Kiyoshi

PY - 2002/1/1

Y1 - 2002/1/1

N2 - In order to clarify the postprandial glucose suppression via α-glucosidase (AGH) inhibitory action by natural compounds, flavonoids were examined in this study. Among the flavonoids (luteolin, kaempferol, chrysin, and galangin), luteolin showed the potent maltase inhibitory activity with the IC50 of 2.3 mM, while less inhibitions were observed against sucrase. In addition, the effects of maltase inhibition by flavonoids were observed in the descending order of potency of luteolin>kaempferol>chrysin>galangin. Apparently, the AGH inhibition power greatly increased with the replacement of hydroxyl groups at 3′ and 4′-position of the B-ring. However, the inhibitory power of luteolin was poorer than a therapeutic drug (acarbose: IC50; 430 nM). As a result of a single oral administration of maltose or sucrose (2 g/kg) in SD rats, no significant change in blood glucose level with the doses of 100 and 200 mg/kg of luteolin was observed. These findings strongly suggested that luteolin given at less than 200 mg/kg did not possess the ability to suppress the glucose production from carbohydrates through the inhibition of AGH action in the gut.

AB - In order to clarify the postprandial glucose suppression via α-glucosidase (AGH) inhibitory action by natural compounds, flavonoids were examined in this study. Among the flavonoids (luteolin, kaempferol, chrysin, and galangin), luteolin showed the potent maltase inhibitory activity with the IC50 of 2.3 mM, while less inhibitions were observed against sucrase. In addition, the effects of maltase inhibition by flavonoids were observed in the descending order of potency of luteolin>kaempferol>chrysin>galangin. Apparently, the AGH inhibition power greatly increased with the replacement of hydroxyl groups at 3′ and 4′-position of the B-ring. However, the inhibitory power of luteolin was poorer than a therapeutic drug (acarbose: IC50; 430 nM). As a result of a single oral administration of maltose or sucrose (2 g/kg) in SD rats, no significant change in blood glucose level with the doses of 100 and 200 mg/kg of luteolin was observed. These findings strongly suggested that luteolin given at less than 200 mg/kg did not possess the ability to suppress the glucose production from carbohydrates through the inhibition of AGH action in the gut.

UR - http://www.scopus.com/inward/record.url?scp=0036490521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036490521&partnerID=8YFLogxK

U2 - 10.1271/bbb.66.689

DO - 10.1271/bbb.66.689

M3 - Article

C2 - 12005074

AN - SCOPUS:0036490521

VL - 66

SP - 689

EP - 692

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 3

ER -