Lycium schweinfurthii: new secondary metabolites and their cytotoxic activities

Ahmed Elbermawi, Ahmed F. Halim, El Sayed S. Mansour, Kadria F. Ahmad, Marwa Elsbaey, Ahmed Ashour, Yhiya Amen, Mohammed M. El-Gamil, Miyamoto Tomofumi, Kuniyoshi Shimizu

Research output: Contribution to journalArticlepeer-review

Abstract

Two new compounds, 11S-methoxy-11,12-dihydro phytuberin (2) and 9S-methoxy-benzocyclononan-7-one (6), together with twenty-six known ones were isolated from Lycium schweinfurthii (Solanaceae). Their planar structure was established by extensive spectroscopic analyses. The absolute configuration of compound 6 was determined by time dependent density functional theory calculations (TDDFT). The cytotoxic potential of the isolates was assessed in cultured skin cancer (G-361) and colon cancer (HCT-116 and CaCo-2) cell lines. Certain flavonoids showed the highest cytotoxic activity, with IC50 values ranging from 7.1 to 63.3µM; meanwhile 5-flurouracil showed IC50 values ranging from 62.4 to >100 µM. All compounds showed minimal toxicity towards normal cells from skin (NHDF-4) and colon (CCD-841), indicating their potential selectivity and safety as cytotoxic candidates.

Original languageEnglish
JournalNatural Product Research
DOIs
Publication statusAccepted/In press - 2021

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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