Lycocasuarines A–C, Lycopodium alkaloids from Lycopodiastrum casuarinoides

Lu Lu Wang, Zhong Bo Zhou, Xin Liu Zhu, Fang Yu Yuan, Tomofumi Miyamoto, Ke Pan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Three lycodine-type Lycopodium alkaloids (1–3) were isolated from Lycopodiastrum casuarinoides. Their structures were elucidated by spectroscopic analysis, single-crystal X-ray crystallography, and computational methods. Compound 1 possesses a rearranged five-membered ring D resulting from C-8/C-15 cleavage and a new C-7/C-15 linkage. Compound 2 is the first Lycopodium alkaloid found to bear an additional carbon (C-17) directly bonded to C-8, which is particularly unusual from a biogenetic point of view. Compounds 1–3 were evaluated for acetylcholinesterase inhibitory activities.

Original languageEnglish
Pages (from-to)4827-4831
Number of pages5
JournalTetrahedron Letters
Volume58
Issue number52
DOIs
Publication statusPublished - Dec 27 2017

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Lycopodium
Alkaloids
Dilatation and Curettage
Spectroscopic analysis
X ray crystallography
X Ray Crystallography
Acetylcholinesterase
Computational methods
Carbon
Single crystals
C 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Lycocasuarines A–C, Lycopodium alkaloids from Lycopodiastrum casuarinoides. / Wang, Lu Lu; Zhou, Zhong Bo; Zhu, Xin Liu; Yuan, Fang Yu; Miyamoto, Tomofumi; Pan, Ke.

In: Tetrahedron Letters, Vol. 58, No. 52, 27.12.2017, p. 4827-4831.

Research output: Contribution to journalArticle

Wang, Lu Lu ; Zhou, Zhong Bo ; Zhu, Xin Liu ; Yuan, Fang Yu ; Miyamoto, Tomofumi ; Pan, Ke. / Lycocasuarines A–C, Lycopodium alkaloids from Lycopodiastrum casuarinoides. In: Tetrahedron Letters. 2017 ; Vol. 58, No. 52. pp. 4827-4831.
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