Lycocasuarines A–C, Lycopodium alkaloids from Lycopodiastrum casuarinoides

Lu Lu Wang, Zhong Bo Zhou, Xin Liu Zhu, Fang Yu Yuan, Tomofumi Miyamoto, Ke Pan

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Three lycodine-type Lycopodium alkaloids (1–3) were isolated from Lycopodiastrum casuarinoides. Their structures were elucidated by spectroscopic analysis, single-crystal X-ray crystallography, and computational methods. Compound 1 possesses a rearranged five-membered ring D resulting from C-8/C-15 cleavage and a new C-7/C-15 linkage. Compound 2 is the first Lycopodium alkaloid found to bear an additional carbon (C-17) directly bonded to C-8, which is particularly unusual from a biogenetic point of view. Compounds 1–3 were evaluated for acetylcholinesterase inhibitory activities.

Original languageEnglish
Pages (from-to)4827-4831
Number of pages5
JournalTetrahedron Letters
Volume58
Issue number52
DOIs
Publication statusPublished - Dec 27 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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