Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats

Hiroko Tomoyori, Octavio Carvajal, Masahiro Nakayama, Taiji Kishi, Masao Sato, Ikuo Ikeda, Katsumi Imaizumi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Rats were fed on a diet containing 0.5% cholesterol oxidation products (oxysterols) or 0.5% cholesterol for 30 min, and their lymph was collected for 7 h. The amount of each of the individual oxysterols absorbed in the lymph depended on the ingested amounts, but the recovery was the highest for 5α,6α-epoxycholesterol (10.5%), this being followed by 7-ketocholesterol (5.8%), cholestanetriol (5.2%), 7β-hydroxycholesterol (4.8%), 7α-hydroxycholesterol (3.4%), 5β,6β-epoxycholesterol (2.2%), and 25-hydroxycholesterol (1.8%). A diet enriched with oxysterol, but not cholesterol, resulted in increased transport of triacylglycerols in the lymph. These results suggest that the absorption rate of oxysterols depends on the type, and indicate that the effect of dietary oxysterols on the lymphatic transport of triacylglycerols differs from that of dietary cholesterol. It therefore remains to be determined which oxysterol was responsible for the triacyglycerol transport.

Original languageEnglish
Pages (from-to)828-834
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Volume66
Issue number4
DOIs
Publication statusPublished - Jan 1 2002

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Dietary Cholesterol
Hydroxycholesterols
Rats
Triglycerides
Cholesterol
Nutrition
Oxidation
Lymph
Diet
Recovery
Oxysterols
5,6-epoxycholesterol

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biotechnology
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats. / Tomoyori, Hiroko; Carvajal, Octavio; Nakayama, Masahiro; Kishi, Taiji; Sato, Masao; Ikeda, Ikuo; Imaizumi, Katsumi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 66, No. 4, 01.01.2002, p. 828-834.

Research output: Contribution to journalArticle

Tomoyori, Hiroko ; Carvajal, Octavio ; Nakayama, Masahiro ; Kishi, Taiji ; Sato, Masao ; Ikeda, Ikuo ; Imaizumi, Katsumi. / Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats. In: Bioscience, Biotechnology and Biochemistry. 2002 ; Vol. 66, No. 4. pp. 828-834.
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