Lymphatic vessel invasion detected by the D2-40 monoclonal antibody is an independent prognostic factor in node-negative esophageal squamous cell carcinoma

Yu Imamura, Masayuki Watanabe, Yohei Nagai, Yoshifumi Baba, Kotaro Hirashima, Ryuichi Karashima, Masaaki Iwatsuki, Naoya Yoshida, Koichi Kinoshita, Junji Kurashige, Ken Ichi Iyama, Hideo Baba

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26 Citations (Scopus)

Abstract

Background and Objectives D2-40 staining has been reported to be useful for both identifying lymphatic vessel invasion (LVI) and counting lymphatic vessel density (LVD) in various cancers. The aim of this study was to clarify the prognostic significance of D2-40 staining in patients with esophageal squamous cell carcinoma (ESCC). Methods A total of 159 consecutive patients with ESCC who underwent an esophagectomy with lymph node dissection were eligible. LVI was diagnosed by both hematoxylin-eosin (LVI-HE) and D2-40 staining (LVI-D2-40) in the largest central sections of the entire tumors, while both the intratumoral and peritumoral LVD were counted by D2-40 staining. The correlation between the prognosis and clinicopathological factors was investigated. Results An univariate analysis revealed that tumor invasion beyond the muscularis propria, lymph node metastasis (LNM), LVI-HE, LVI-D2-40, high intratumoral LVD, and blood vessel invasion correlated with worse patients' prognosis (P<0.05). A multivariate analysis revealed LNM to be the only independent prognostic factor in all cases (P=0.0083). On the other hand, when the prognostic factors of 83 patients without LNM were investigated, LVI-D2-40 was revealed to be the only independent prognostic factor (P=0.048). Conclusions LVI detected by D2-40 staining was an independent prognostic factor in patients with node-negative ESCC.

Original languageEnglish
Pages (from-to)277-283
Number of pages7
JournalJournal of Surgical Oncology
Volume105
Issue number3
DOIs
Publication statusPublished - Mar 1 2012

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Lymphatic Vessels
Staining and Labeling
Lymph Nodes
Neoplasm Metastasis
Esophageal Squamous Cell Carcinoma
monoclonal antibody D2-40
Neoplasms
Esophagectomy
Hematoxylin
Eosine Yellowish-(YS)
Lymph Node Excision
Blood Vessels
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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Lymphatic vessel invasion detected by the D2-40 monoclonal antibody is an independent prognostic factor in node-negative esophageal squamous cell carcinoma. / Imamura, Yu; Watanabe, Masayuki; Nagai, Yohei; Baba, Yoshifumi; Hirashima, Kotaro; Karashima, Ryuichi; Iwatsuki, Masaaki; Yoshida, Naoya; Kinoshita, Koichi; Kurashige, Junji; Iyama, Ken Ichi; Baba, Hideo.

In: Journal of Surgical Oncology, Vol. 105, No. 3, 01.03.2012, p. 277-283.

Research output: Contribution to journalArticle

Imamura, Y, Watanabe, M, Nagai, Y, Baba, Y, Hirashima, K, Karashima, R, Iwatsuki, M, Yoshida, N, Kinoshita, K, Kurashige, J, Iyama, KI & Baba, H 2012, 'Lymphatic vessel invasion detected by the D2-40 monoclonal antibody is an independent prognostic factor in node-negative esophageal squamous cell carcinoma', Journal of Surgical Oncology, vol. 105, no. 3, pp. 277-283. https://doi.org/10.1002/jso.22079
Imamura, Yu ; Watanabe, Masayuki ; Nagai, Yohei ; Baba, Yoshifumi ; Hirashima, Kotaro ; Karashima, Ryuichi ; Iwatsuki, Masaaki ; Yoshida, Naoya ; Kinoshita, Koichi ; Kurashige, Junji ; Iyama, Ken Ichi ; Baba, Hideo. / Lymphatic vessel invasion detected by the D2-40 monoclonal antibody is an independent prognostic factor in node-negative esophageal squamous cell carcinoma. In: Journal of Surgical Oncology. 2012 ; Vol. 105, No. 3. pp. 277-283.
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abstract = "Background and Objectives D2-40 staining has been reported to be useful for both identifying lymphatic vessel invasion (LVI) and counting lymphatic vessel density (LVD) in various cancers. The aim of this study was to clarify the prognostic significance of D2-40 staining in patients with esophageal squamous cell carcinoma (ESCC). Methods A total of 159 consecutive patients with ESCC who underwent an esophagectomy with lymph node dissection were eligible. LVI was diagnosed by both hematoxylin-eosin (LVI-HE) and D2-40 staining (LVI-D2-40) in the largest central sections of the entire tumors, while both the intratumoral and peritumoral LVD were counted by D2-40 staining. The correlation between the prognosis and clinicopathological factors was investigated. Results An univariate analysis revealed that tumor invasion beyond the muscularis propria, lymph node metastasis (LNM), LVI-HE, LVI-D2-40, high intratumoral LVD, and blood vessel invasion correlated with worse patients' prognosis (P<0.05). A multivariate analysis revealed LNM to be the only independent prognostic factor in all cases (P=0.0083). On the other hand, when the prognostic factors of 83 patients without LNM were investigated, LVI-D2-40 was revealed to be the only independent prognostic factor (P=0.048). Conclusions LVI detected by D2-40 staining was an independent prognostic factor in patients with node-negative ESCC.",
author = "Yu Imamura and Masayuki Watanabe and Yohei Nagai and Yoshifumi Baba and Kotaro Hirashima and Ryuichi Karashima and Masaaki Iwatsuki and Naoya Yoshida and Koichi Kinoshita and Junji Kurashige and Iyama, {Ken Ichi} and Hideo Baba",
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AU - Imamura, Yu

AU - Watanabe, Masayuki

AU - Nagai, Yohei

AU - Baba, Yoshifumi

AU - Hirashima, Kotaro

AU - Karashima, Ryuichi

AU - Iwatsuki, Masaaki

AU - Yoshida, Naoya

AU - Kinoshita, Koichi

AU - Kurashige, Junji

AU - Iyama, Ken Ichi

AU - Baba, Hideo

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N2 - Background and Objectives D2-40 staining has been reported to be useful for both identifying lymphatic vessel invasion (LVI) and counting lymphatic vessel density (LVD) in various cancers. The aim of this study was to clarify the prognostic significance of D2-40 staining in patients with esophageal squamous cell carcinoma (ESCC). Methods A total of 159 consecutive patients with ESCC who underwent an esophagectomy with lymph node dissection were eligible. LVI was diagnosed by both hematoxylin-eosin (LVI-HE) and D2-40 staining (LVI-D2-40) in the largest central sections of the entire tumors, while both the intratumoral and peritumoral LVD were counted by D2-40 staining. The correlation between the prognosis and clinicopathological factors was investigated. Results An univariate analysis revealed that tumor invasion beyond the muscularis propria, lymph node metastasis (LNM), LVI-HE, LVI-D2-40, high intratumoral LVD, and blood vessel invasion correlated with worse patients' prognosis (P<0.05). A multivariate analysis revealed LNM to be the only independent prognostic factor in all cases (P=0.0083). On the other hand, when the prognostic factors of 83 patients without LNM were investigated, LVI-D2-40 was revealed to be the only independent prognostic factor (P=0.048). Conclusions LVI detected by D2-40 staining was an independent prognostic factor in patients with node-negative ESCC.

AB - Background and Objectives D2-40 staining has been reported to be useful for both identifying lymphatic vessel invasion (LVI) and counting lymphatic vessel density (LVD) in various cancers. The aim of this study was to clarify the prognostic significance of D2-40 staining in patients with esophageal squamous cell carcinoma (ESCC). Methods A total of 159 consecutive patients with ESCC who underwent an esophagectomy with lymph node dissection were eligible. LVI was diagnosed by both hematoxylin-eosin (LVI-HE) and D2-40 staining (LVI-D2-40) in the largest central sections of the entire tumors, while both the intratumoral and peritumoral LVD were counted by D2-40 staining. The correlation between the prognosis and clinicopathological factors was investigated. Results An univariate analysis revealed that tumor invasion beyond the muscularis propria, lymph node metastasis (LNM), LVI-HE, LVI-D2-40, high intratumoral LVD, and blood vessel invasion correlated with worse patients' prognosis (P<0.05). A multivariate analysis revealed LNM to be the only independent prognostic factor in all cases (P=0.0083). On the other hand, when the prognostic factors of 83 patients without LNM were investigated, LVI-D2-40 was revealed to be the only independent prognostic factor (P=0.048). Conclusions LVI detected by D2-40 staining was an independent prognostic factor in patients with node-negative ESCC.

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