Lymphocyte-to-Monocyte Ratio Is a Predictor of Survival After Liver Transplantation for Hepatocellular Carcinoma

Yohei Mano, Tomoharu Yoshizumi, Kyohei Yugawa, Masafumi Ohira, Takashi Motomura, Takeo Toshima, Shinji Itoh, Noboru Harada, Toru Ikegami, Yuji Soejima, Yoshihiko Maehara

Research output: Contribution to journalArticle

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Abstract

Recent studies revealed that systemic inflammation was correlated with poorer prognosis in various cancers. We investigated the prognostic value of the lymphocyte-to-monocyte ratio (LMR) in patients who underwent living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). We retrospectively analyzed the records of 216 patients who underwent LDLT for HCC. Patients were divided into high (n = 126) and low (n = 90) LMR groups. Their clinicopathological parameters and survival times were compared. To determine the mechanisms of the change in the LMR, we performed immunohistochemical analyses of CD3 and CD68 expression. A low LMR was significantly associated with a high Model for End-Stage Liver Disease score; a high Child-Pugh score; elevation of alpha-fetoprotein, des-gamma-carboxyprothrombin, and neutrophil-to-lymphocyte ratio; larger tumor size; more tumors; and poorer prognosis. A low LMR was associated with poor prognosis and represented an independent prognostic factor, particularly among patients beyond the Milan criteria. The ratio of CD3-positive to CD68-positive cells was significantly lower in the low-LMR group. In conclusion, our results show that the LMR was an independent predictor of survival of patients with HCC beyond the Milan criteria who underwent LDLT. The LMR reflected the immune status of the tumor microenvironment.

Original languageEnglish
Pages (from-to)1603-1611
Number of pages9
JournalLiver Transplantation
Volume24
Issue number11
DOIs
Publication statusPublished - Nov 2018

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Liver Transplantation
Monocytes
Hepatocellular Carcinoma
Lymphocytes
Survival
Living Donors
Neoplasms
End Stage Liver Disease
Tumor Microenvironment
alpha-Fetoproteins
Neutrophils
Inflammation

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology
  • Transplantation

Cite this

Lymphocyte-to-Monocyte Ratio Is a Predictor of Survival After Liver Transplantation for Hepatocellular Carcinoma. / Mano, Yohei; Yoshizumi, Tomoharu; Yugawa, Kyohei; Ohira, Masafumi; Motomura, Takashi; Toshima, Takeo; Itoh, Shinji; Harada, Noboru; Ikegami, Toru; Soejima, Yuji; Maehara, Yoshihiko.

In: Liver Transplantation, Vol. 24, No. 11, 11.2018, p. 1603-1611.

Research output: Contribution to journalArticle

Mano, Yohei ; Yoshizumi, Tomoharu ; Yugawa, Kyohei ; Ohira, Masafumi ; Motomura, Takashi ; Toshima, Takeo ; Itoh, Shinji ; Harada, Noboru ; Ikegami, Toru ; Soejima, Yuji ; Maehara, Yoshihiko. / Lymphocyte-to-Monocyte Ratio Is a Predictor of Survival After Liver Transplantation for Hepatocellular Carcinoma. In: Liver Transplantation. 2018 ; Vol. 24, No. 11. pp. 1603-1611.
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