Lymphoid lineage fate decision of hematopoietic stem cells

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

To understand the mechanism in lymphoid development, it is critical to identify developmental intermediates downstream of hematopoietic stem cells, including cells responsible for seeding the thymus. Although early studies showed that hematopoietic stem cells choose either the myeloid-erythroid or the lymphoid pathway, recent data suggest that myelo-lymphoid precursors lacking erythroid potential exist in early hematopoiesis before cells are fully committed to the lymphoid lineage. We here summarize the phenotype and functional properties of such progenitors and the current developmental map for the lymphoid lineage.

Original languageEnglish
Title of host publicationHematopoietic Stem Cells VII
PublisherBlackwell Publishing Inc.
Pages18-25
Number of pages8
ISBN (Print)9781573317610
DOIs
Publication statusPublished - Jan 1 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1176
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Akashi, K. (2009). Lymphoid lineage fate decision of hematopoietic stem cells. In Hematopoietic Stem Cells VII (pp. 18-25). (Annals of the New York Academy of Sciences; Vol. 1176). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.04570.x